TY - JOUR
TI - Primary malignant mesothelioma of the peritoneum: a clinical and
immunohistochemical study
AU - Markaki, S
AU - Protopapas, A
AU - Milingos, S
AU - Lazaris, D and
AU - Antsaklis, A
AU - Michalas, S
JO - Gynecologic Oncology
PY - 2005
VL - 96
TODO - 3
SP - 860-864
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 0090-8258, 1095-6859
TODO - 10.1016/j.ygyno.2004.11.014
TODO - malignant mesothelioma; peritoneum; immunohistochemistry
TODO - Background. Primary peritoneal mesothelioma is regarded as a fatal
disease that presents with progressive ascites at a relatively late
stage of its natural history. Differential diagnosis between this rare
tumor and both serous papillary carcinoma of the peritoneum and ovary
can be problematic.
Case. A 54-year-old woman presented to our institution with a 4-month
history of dull epigastric pain and increased abdominal girth.
Exploratory laparotomy revealed the presence of extensive
intraperitoneal dissemination of a malignant neoplasm without a
recognizable primary site. Suboptimal cytoreduction was carried out, and
histological diagnosis was that of a malignant epithelioid mesothelioma.
This was confirmed with a panel of immunohistochemical markers. The
patient despite having a complete response after adjuvant chemotherapy
died 18 months after primary surgery.
Conclusion. No single immunohistochemical stain is pathognomonic of
peritoneal primary malignant mesothelioma (PMM), and the results of a
panel of antibodies should be interpreted to set the diagnosis. (c) 2004
Published by Elsevier Inc.
ER -