TY - JOUR
TI - Efficacy and safety of intermittent, long-term, concomitant dobutamine
and levosimendan infusions in severe heart failure refractory to
dobutamine alone
AU - Nanas, JN
AU - Papazoglou, P
AU - Tsagalou, EP
AU - Ntalianis, A and
AU - Tsolakis, E
AU - Terrovitis, JV
AU - Kanakakis, J
AU - Nanas, SN and
AU - Alexopoulos, GP
AU - Anastasiou-Nana, MI
JO - AMERICAN JOURNAL OF CARDIOLOGY
PY - 2005
VL - 95
TODO - 6
SP - 768-771
PB - Excerpta Medica Inc.
SN - 0002-9149
TODO - 10.1016/j.amjcard.2004.11.033
TODO - null
TODO - Thirty-six consecutive patients in New York Heart Association functional
class IV, who were resistant to 24-hour continuous dobutamine infusion,
were treated with continuous infusions of dobutamine 10 mu g/kg/min for
>= 48 hours (group I, In = 18), followed by weekly intermittent 8-hour
infusions or more often if needed. In group II (n = 18), after the
initial 24-hour infusion of dobutamine, a 24-hour levosimendan infusion
was added followed by biweekly 24-hour infusions. The addition of
intermittent levosimendan infusions prolonged the survival of patients
with advanced heart failure refractory to intermittent dobutamine
infusions (45-day survival rates were 6% and 61% in groups I and II,
respectively; p = 0.0002, log-rank test). (c) 2005 by Excerpta Medica
Inc.
ER -