TY - JOUR
TI - The intrauterine origin of male breast cancer: a birth order study in
Denmark
AU - Sorensen, HT
AU - Olsen, ML
AU - Mellemkjaer, L
AU - Lagiou, P
AU - Olsen,
AU - JH
AU - Olsen, J
JO - European Journal of Cancer Prevention: The Official Journal of the European Cancer Prevention Organisation (ECP)
PY - 2005
VL - 14
TODO - 2
SP - 185-186
PB - Lippincott, Williams & Wilkins
SN - 0959-8278
TODO - 10.1097/00008469-200504000-00016
TODO - birth order; case-control; in utero; male breast cancer
TODO - First pregnancies are known to have higher oestrogen levels than later
ones and first-born women are at increased breast cancer risk compared
with later-born women. We hypothesized that a birth order effect might
be even more evident in male breast cancer patients, in whom oestrogens
in adult life are generally low. In a population-based study in Denmark
involving 77 male breast cancer patients and 288 population controls,
first-born men compared with later-born men had a relative risk of 1.71
for the disease (95% confidence interval (Cl) 1.00-2.92). This result
is in line with that seen in female breast cancer cases and indicates
that male breast cancer may have roots in the intrauterine life,
oestrogens being a likely mediator. (c) 2005 Lippincott Williams &
Wilkins.
ER -