TY - JOUR
TI - Estradiol and leptin as conditional prognostic IVF markers
AU - Anifandis, G
AU - Koutselini, E
AU - Louridas, K
AU - Liakopoulos, V and
AU - Leivaditis, K
AU - Mantzavinos, T
AU - Sioutopoulou, D
AU - Vamvakopoulos,
AU - N
JO - MOLECULAR HUMAN REPRODUCTION
PY - 2005
VL - 129
TODO - 4
SP - 531-534
PB - BioScientifica Ltd
SN - null
TODO - 10.1530/rep.1.00567
TODO - null
TODO - We studied the concentration of serum estradiol and serum and follicular
fluid leptin in 200 women undergoing their first in vitro fertilization
with embryo transfer (IVF-ET) program at the time of human chorionic
gonadotrophin administration and oocyte retrieval, in an attempt to
assess their concerted role on embryo quality and the prognosis of IVF
outcome. Low serum (46.49 +/- 8.4 ng/ml) and follicular fluid (52 +/-
9.8 ng/ml) leptin levels were associated with a high number of
‘good-quality’ embryos (73.6%) and high implantation (11.2%) and
pregnancy (35.8%) rates and were observed in women with normal peak
estradiol levels of between 1000 and 2000 pg/ml. It appears that leptin
and estradiol interact coordinately in a concentration-dependent manner
to control IVF outcome. Further studies will be required to substantiate
and clarify the mechanism of proposed conditional interaction between
the two hormonal systems.
ER -