TY - JOUR
TI - Insulin-stimulated rates of glucose uptake in muscle in hyperthyroidism: The importance of blood flow
AU - Dimitriadis, G.
AU - Mitrou, P.
AU - Lambadiari, V.
AU - Boutati, E.
AU - Maratou, E.
AU - Koukkou, E.
AU - Panagiotakos, D.
AU - Tountas, N.
AU - Economopoulos, T.
AU - Raptis, S.A.
JO - JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
PY - 2008
VL - 93
TODO - 6
SP - 2413-2415
PB - Japan Endocrine Society
SN - 0021-972X
TODO - 10.1210/jc.2007-2832
TODO - glucose;  insulin, adult;  article;  clinical article;  controlled study;  female;  forearm blood flow;  glucose transport;  hormone action;  human;  hyperthyroidism;  male;  muscle blood flow;  plethysmography;  postprandial state;  priority journal
TODO - Background: In hyperthyroidism, although hepatic insulin resistance is well established, information on the effects of insulin on glucose uptake in skeletal muscle is variable. Methods: To investigate this, a meal was given to nine hyperthyroid (HR) and seven euthyroid (EU) subjects. Blood was withdrawn for 360 min from a forearm deep vein and the radial artery for measurements of insulin and glucose. Forearm blood flow (BF) was measured with strain-gauge plethysmography. Glucose flux was calculated as arteriovenous difference multiplied by BF and fractional glucose extraction as arteriovenous difference divided by arterial glucose concentrations. Results: Both groups displayed comparable postprandial glucose levels, with the HR having higher insulin levels than the EU. In the forearm of HR vs. EU: 1) glucose flux was similar [area under the curve (AUC)0-360 673 ± 143 vs. 826 ± 157 μmol per 100 ml tissue]; 2) BF was increased (AUC0-360 3076 ± 338 vs. 1745 ± 145 ml per 100 ml tissue, P = 0.005); and 3) fractional glucose extraction was decreased (AUC0-360 14.5 ± 3 vs. 32 ± 5%min, P = 0.03). Conclusions: These results suggest that, in hyperthyroidism, insulin-stimulated glucose uptake in muscle is impaired; this defect is corrected, at least in part, by the increases in BF. Copyright © 2008 by The Endocrine Society.
ER -