TY - JOUR
TI - Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma
AU - Abazis-Stamboulieh, D.
AU - Oikonomou, P.
AU - Papadoulis, N.
AU - Panayiotidis, P.
AU - Vrakidou, E.
AU - Tsezou, A.
JO - Clinical Lymphoma Myeloma and Leukemia
PY - 2007
VL - 48
TODO - 11
SP - 2196-2203
PB - 
SN - null
TODO - 10.1080/10428190701615892
TODO - interleukin 1 receptor blocking agent;  interleukin 1alpha;  interleukin 1beta, adult;  aged;  article;  cancer susceptibility;  cell maturation;  cell proliferation;  controlled study;  disease course;  DNA polymorphism;  female;  gene control;  genetic predisposition;  human;  immune system;  major clinical study;  male;  multiple myeloma;  priority journal;  single nucleotide polymorphism, Adult;  Aged;  Aged, 80 and over;  Case-Control Studies;  Female;  Gene Frequency;  Genotype;  Greece;  Humans;  Interleukin 1 Receptor Antagonist Protein;  Interleukin-1alpha;  Interleukin-1beta;  Linkage (Genetics);  Male;  Middle Aged;  Multiple Myeloma;  Polymorphism, Single Nucleotide
TODO - Interleukin-1 (IL-1) is a cytokine involved in the maturation and proliferation of B cells and plays a significant role in the development of lytic bone lesions, a major clinical feature of multiple myeloma (MM) patients. Genes that regulate products involved in the immune system are highly polymorphic and contribute to inter-individual differences that can influence the genetic predisposition and progression of particular diseases and cancers. In this study, we investigated the correlation between the single nucleotide polymorphisms IL1A -889, IL1B -511, IL1B +3954, IL1RN Mspa1 +11100 and susceptibility to MM in 74 patients and 160 controls. We found that individuals possessing IL1A -889 CT polymorphism had a higher risk in developing MM. Moreover, genotypes IL1B -511 CC, IL1B +3954 CC, IL-1RN Mspa1 +11100 CC and the combination of IL 1B +3954 CC with IL1B -511 CC or IL-1RN Mspa1 +11100 CC exerted a protective effect in individuals possessing them.
ER -