TY - JOUR
TI - The level of hypotension during hemorrhagic shock is a major determinant of the post-resuscitation systemic inflammatory response: An experimental study
AU - Douzinas, E.E.
AU - Andrianakis, I.
AU - Livaditi, O.
AU - Paneris, P.
AU - Tasoulis, M.
AU - Pelekanou, A.
AU - Betrosian, A.
AU - Giamarellos-Bourboulis, E.J.
JO - BMC Physiology
PY - 2008
VL - 8
TODO - 1
SP - null
PB - 
SN - 1472-6793
TODO - 10.1186/1472-6793-8-15
TODO - aminotransferase;  creatinine;  cytokine;  interleukin 1beta;  interleukin 6;  malonaldehyde;  Ringer lactate solution;  tumor necrosis factor alpha;  cytokine, aminotransferase blood level;  animal experiment;  animal model;  article;  blood transfusion;  clinical evaluation;  control group;  controlled study;  creatinine blood level;  experimental study;  hemorrhagic shock;  hypotension;  mean arterial pressure;  mononuclear cell;  nonhuman;  rabbit;  resuscitation;  statistical significance;  systemic inflammatory response syndrome;  animal;  blood;  blood pressure;  heart muscle ischemia;  hypotension;  pathophysiology;  resuscitation;  systemic inflammatory response syndrome;  treatment outcome, Animals;  Blood Pressure;  Cytokines;  Hypotension;  Myocardial Ischemia;  Rabbits;  Resuscitation;  Shock, Hemorrhagic;  Systemic Inflammatory Response Syndrome;  Treatment Outcome
TODO - Background. To evaluate whether the level of hypotension during hemorrhagic shock may influence the oxidative and inflammatory responses developed during post-ischemic resuscitation. Methods. Fifteen rabbits were equally allocated into three groups: sham-operated (group sham); bled within 30 minutes to mean arterial pressure (MAP) of 40 mmHg (group shock-40); bled within 30 minutes to MAP of 30 mmHg (group shock-30). Shock was maintained for 60 min. Resuscitation was performed by reinfusing shed blood with two volumes of Ringer's lactate and blood was sampled for estimation of serum levels aminotransferases, creatinine, TNF-α, IL-1β, IL-6, malondialdehyde (MDA) and total antioxidant status (TAS) and for the determination of oxidative burst of polymorhonuclears (PMNs) and mononuclear cells (MCs). Results. Serum AST of group shock-30 was higher than that of group shock-40 at 60 and 120 minutes after start of resuscitation; serum creatinine of group shock-30 was higher than group shock-40 at 120 minutes. Measured cytokines, MDA and cellular oxidative burst of groups, shock-40 and shock-30 were higher than group sham within the first 60 minutes after start of resuscitation. Serum concentrations of IL-1β, IL-6 and TNF-α of group shock-30 were higher than group shock-40 at 120 minutes (p < 0.05). No differences were found between two groups regarding serum MDA and TAS and oxidative burst on PMNs and MCs but both groups were different to group sham. Conclusion. The level of hypotension is a major determinant of the severity of hepatic and renal dysfunction and of the inflammatory response arising during post-ischemic hemorrhagic shock resuscitation. These findings deserve further evaluation in the clinical setting. © 2008 Douzinas et al; licensee BioMed Central Ltd.
ER -