TY - JOUR
TI - Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis
AU - Tsirigotis, P.
AU - Papageorgiou, S.
AU - Abatzis, D.
AU - Athanatou, S.
AU - Girkas, C.
AU - Pappa, V.
AU - Pangalos, C.
AU - Papageorgiou, E.
AU - Dervenoulas, J.
AU - Raptis, S.
JO - CANCER GENETICS AND CYTOGENETICS
PY - 2005
VL - 161
TODO - 1
SP - 78-81
PB - 
SN - 0165-4608
TODO - 10.1016/j.cancergencyto.2004.12.016
TODO - cytarabine;  etoposide;  idarubicin, acute granulocytic leukemia;  adult;  article;  bone marrow biopsy;  cancer chemotherapy;  cancer cytodiagnosis;  cancer prevention;  case report;  chromosome 8;  female;  flow cytometry;  human;  priority journal;  prognosis;  recurrent cancer;  relapse;  salvage therapy;  tetrasomy, Adult;  Aneuploidy;  Chromosome Aberrations;  Chromosomes, Human, Pair 8;  Female;  Humans;  In Situ Hybridization, Fluorescence;  Karyotyping;  Leukemia, Myelocytic, Acute;  Prognosis
TODO - Tetrasomy 8 is an extremely rare chromosome abnormality, one that has been reported in only a few cases with myeloid malignancies. The majority of reported cases consist of acute myelogenous leukemias (AML) of monocytic lineage. In slightly more than half of the patients, tetrasomy 8 was the single cytogenetic abnormality. Fluorescence in situ hybridization revealed tetrasomy 8 and trisomy 8 concurrently in all but one of the bone marrow samples. The clonal relationship between trisomy 8 and tetrasomy 8 in these cases remains to be clarified. Patients with tetrasomy 8 have a poor prognosis, and only 1 out of 33 patients was free of disease 3 years after autologous bone marrow transplantation. Here, we report the case of a 25-year-old female patient with monocytic leukemia and tetrasomy 8. © 2005 Elsevier Inc. All rights reserved.
ER -