TY - JOUR
TI - Moc-31, fibronectin and CEA in the differential diagnosis of malignant effusions: An immunocytochemical study
AU - Athanassiadou, P.
AU - Gonidi, M.
AU - Liossi, A.
AU - Petrakakou, E.
AU - Nakopoulou, L.
AU - Zerva, C.
AU - Athanassiades, P.
JO - Pathology and Oncology Research
PY - 2000
VL - 6
TODO - 2
SP - 100-103
PB - Kluwer Academic Publishers
SN - 1219-4956
TODO - 10.1007/BF03032357
TODO - antibody;  carcinoembryonic antigen;  fibronectin;  membrane protein, article;  controlled study;  effusion;  human;  immunocytochemistry;  major clinical study;  malignant neoplastic disease
TODO - In discriminating benign and malignant origins of cytologically suspicious effusion smears a panel of antibodies against carcinoembryonic antigen (CEA), Fibronectin (F) and MOC-31 was used with immunocytochemical techniques. One hundred and thirty seven effusions were studied of which 107 had a malignant and 30 a benign aetiology as determined by clinical and histological examination. Cytologically 24 were diagnosed as benign, 97 as malignant and 14 as suspicious. Staining for F was positive in all effusions of benign and 3 of malignant origin. MOC-31 was positive in 95 (88.8%) of effusions of malignant origin but none of benign origin. Positive CEA was observed in 43% of effusions of malignant origin and in 10 of benign origin. The combination of MOC-31 positivity measured the sensitivity and specificity of the cytological examination in cases where the cytological examination result was suspicious as did F positivity improve the sensitivity for a benign origin of the effusion. Positivity or negativity for CEA is less valuable than the other parameters.
ER -