TY - JOUR
TI - Does soluble triggering receptor expressed on myeloid cells-1 play any
role in the pathogenesis of septic shock?
AU - Routsi, C
AU - Giamarellos-Bourboulis, EJ
AU - Antonopoulou, A and
AU - Kollias, S
AU - Siasiakou, S
AU - Koronaios, A
AU - Zakynthinos, S and
AU - Armaganidis, A
AU - Giamarellou, H
AU - Roussos, C
JO - Clinical and Experimental Immunology
PY - 2005
VL - 142
TODO - 1
SP - 62-67
PB - Wiley
SN - null
TODO - 10.1111/j.1365-2249.2005.02887.X
TODO - sepsis; septic shock; sTREM-1; survival
TODO - In order to define the significance of soluble triggering receptor
expressed on myeloid cells-1 (sTREM-1) upon progression from sepsis or
severe sepsis to septic shock a prospective study was designed with 90
enrolled patients with septic syndrome due to ventilator-associated
pneumonia. Blood was sampled on seven consecutive days upon initiation
of symptoms and concentrations of tumour necrosis factor-alpha (TNF
alpha), interleukin-6 (IL-6), IL-8 and sTREM-1 were estimated in serum
by an enzymeimmunoassay. No differences in concentrations of TNF alpha,
IL-6 and IL-8 were found between patients with sepsis, severe sepsis and
septic shock on the first day of presentation of symptoms. Patients
presenting with septic shock had concentrations of sTREM-1 significantly
higher than both patients with sepsis and severe sepsis on the first
day; no difference was found between patients with sepsis and severe
sepsis. A positive correlation was detected between sTREM-1 and the
white blood cell count. Serum levels of sTREM-1 were significantly lower
in patients where VAP resolved compared to those where VAP did not
resolve; similar findings were noted between patients who eventually
survived and those who died. IL-6 followed the kinetics of sTREM-1 in
correlation to patients’s prognosis; levels of TNF alpha and IL-8 were
unrelated to prognosis. It is concluded that sTREM-1 is particularly
increased upon evolution from sepsis or severe sepsis to septic shock.
Its sustained increase is an indication of poor outcome. The underlined
pathophysiological role of sTREM-1 for the transition from sepsis or
severe sepsis to septic shock might constitute a novel target for
immunomodulatory therapy.
ER -