TY - JOUR
TI - Local application of volatile anesthetics attenuates the response to a
mechanical stimulus in humans
AU - Fassoulaki, A
AU - Skouteri, I
AU - Siafaka, I
AU - Sarantopoulos, C
JO - CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
PY - 2005
VL - 52
TODO - 9
SP - 951-957
PB - Springer-Verlag
SN - null
TODO - 10.1007/BF03022057
TODO - null
TODO - Purpose: Volatile anesthetics may cause local hyperalgesia and/or
analgesia. This double-blind randomized study investigated the effect of
these medications when applied locally on the response to a mechanical
stimulus.
Methods: In experiment I, standard commercial preparations of halothane
( mL, isoflurane 1.5 mL and sevoflurane 2.7 mL were randomly applied on
the forearm of 30 volunteers for 30 min, after which the response to a
mechanical stimulus was recorded. The other forearm received water as
control. The next day, the experiment for each anesthetic was repeated
in a reverse fashion. Thirty minutes after the application, the response
to a standardized mechanical stimulus was recorded. In experiments 2 and
3, the response to the same mechanical stimulus was tested after local
applications of 2, 4, and 6 mL of halothane or after a local application
of 5 mL sevoflurane respectively.
Results: Low doses of the three anesthetics did not alter the response
to the mechanical stimulus (F = 3.055, df = 1,174, P = 0.082). Two, 4,
and 6 mL of halothane attenuated the response to the mechanical stimulus
by 36%, 27% and 29% respectively (F = 9.586, df = 1, 114, P = 0.002).
Five millilitres of sevoflurane attenuated the response to the
mechanical stimulus by 36% (F = 5.111, df = 19, P < 0.001).
Conclusion: Low liquid volumes of volatile anesthetics, when applied
locally to the skin, did not influence the response to a mechanical
stimulus, but higher volumes attenuated this response.
ER -