TY - JOUR
TI - The outcome of advanced or recurrent non-squamous carcinoma of the
uterine cervix after platinum-based combination chemotherapy
AU - Kastritis, E
AU - Bamias, A
AU - Efstathiou, E
AU - Gika, D
AU - Bozas, G
AU - and Zorzou, P
AU - Sarris, K
AU - Papadimitriou, C
AU - Dimopoulos, MA
JO - Gynecologic Oncology
PY - 2005
VL - 99
TODO - 2
SP - 376-382
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 0090-8258, 1095-6859
TODO - 10.1016/j.ygyno.2005.06.024
TODO - cervical cancer; chemotherapy; non-squamous; platinum; recurrent
TODO - Background. Data about the outcome and prognostic factors in the group
of patients with non-squamous cell advanced or recurrent carcinomas of
the uterine cervix are limited. We compared the outcome of patients with
non-squamous with that of squamous cell carcinomas after platinum-based
combination chemotherapy as first line therapy for stage IV or recurrent
cervical carcinoma.
Patients and methods. A total of 200 patients with stage IV or recurrent
carcinomas of the cervix received platinum-based combination
chemotherapy and were included in our analysis.
Results. There were 58 patients with non-squamous and 142 patients with
squamous cell carcinomas. Response to chemotherapy was 53.5% in
non-squamous vs. 43.5% in squamous carcinomas. Histology was not an
independent predictor of turner response (P = 0.797). Response rates
were lower in patients with relapse only in a previously irradiated area
in both squamous (26.9% vs. 53.5%, P = 0.005) and non-squamous
carcinomas (47.1 % vs. 65%, P = 0.270). Weight loss was the only
significant predictor of survival in non-squamous histology patients (P
< 0.0001). There was no significant difference in median survival
between squamous (11.57 months [95% CI 9.35 - 13.79]) and
non-squamous carcinomas (19.05 months [95% CI 13.63 - 24.47]) (P =
0.064). After adjustment for independent prognostic factors (ECOG
performance status and weight loss), differences in survival remained
not significant.
Conclusion. Our study showed a similar outcome for both squamous and
non-squamous stage IV or recurrent cervical carcinomas treated with
platinum-based combination chemotherapy. (c) 2005 Elsevier Inc. All
rights reserved.
ER -