TY - JOUR
TI - Delayed effusive pericarditis and recurrent pleural effusion after
radiation treatment for Hodgkin's disease responsive to per os
doxycycline
AU - Fragoulis, KN
AU - Handrinou, E
AU - Papadopoulos, V
AU - Dardoufas, K and
AU - Falagas, ME
JO - European Journal of Haematology
PY - 2006
VL - 76
TODO - 2
SP - 176-179
PB - Wiley
SN - 0902-4441, 1600-0609
TODO - 10.1111/j.0902-4441.2005.00577.x
TODO - lymphoma; postradiation; sclerosing agent
TODO - We present our experience with a patient with effusive pericarditis and
recurrent pleural effusion that first developed 23 yr after radiation
treatment for the nodular sclerosis type of Hodgkin’s disease. Extensive
diagnostic work up including pericardial and pleural biopsy, excluded
any other cause (than radiation) of the recurrent pleural effusion.
Pericarditis and pleural effusion were not controlled with regimens
including steroid and non-steroid anti-inflammatory agents. The fluid
collections improved only with per os doxycycline (100 mg twice a day).
Four episodes of recurrent pleural effusions were also controlled with
per os doxycycline. Although the concentration of doxycycline in the
pericardial and pleural fluid when given orally is smaller compared with
that achieved by direct installation of the agent, the fact that all
episodes of pleural effusion improved with an agent commonly used for
pleurodesis is intriguing.
ER -