TY - JOUR
TI - Short-term effect of orlistat on dietary glycotoxins in healthy women
and women with polycystic ovary syndrome
AU - Diamanti-Kandarakis, E
AU - Piperi, C
AU - Alexandraki, K and
AU - Katsilambros, N
AU - Kouroupi, E
AU - Papailiou, J
AU - Lazaridis, S and
AU - Koulouri, E
AU - Kandarakis, HA
AU - Douzinas, EE
AU - Creatsas, G and
AU - Kalofoutis, A
JO - Metabolism: Clinical and Experimental
PY - 2006
VL - 55
TODO - 4
SP - 494-500
PB - W B SAUNDERS CO-ELSEVIER INC
SN - 0026-0495
TODO - 10.1016/j.metabol.2005.10.011
TODO - null
TODO - Exogenous advanced glycation endproducts (AGEs, known atherogenic
molecules) abundant in everyday precooked, rich in fat, overheated meals
can possibly contribute to the increased risk for diabetes and
cardiovascular disease in women with polycystic ovary syndrome (PCOS).
The aim of the present study was to investigate the effect of a lipase
inhibitor on absorbed food glycotoxins in healthy women and those with
PCOS. A 2-day protocol was followed. In the first day, a meal rich in
AGE was provided, which on the second day was followed by two 120-mg
capsules of lipase inhibitor, orlistat. Serum AGE levels were evaluated
at baseline (0 hours), and at 3 and 5 hours postmeal during the study.
Thirty-six women were Studied, 15 controls (mean age, 28.80 +/- 5.47
years; body mass index, 25.85 +/- 6.73 kg/m(2)) and 21 with PCOS (mean
age, 25.29 +/- 5.06 years; body mass index, 30.40 +/- 7.51 kg/m(2))
(University Hospital, Athens, Greece, institutional practice). Serum AGE
levels, on day 1, were significantly increased both in the control group
and in the PCOS group as compared with basal values (control group,
14.1%; PCOS group, 6.0%; P <.001). The corresponding rise was
significantly lower on day 2 when the same meal was combined with
orlistat (control group, 4.1%; PCOS group, 2.0%; P <.01). A limitation
of the study is that it is a nonplacebo, nonrandomized therapeutic trial
where each Subject is considered as its own control. In conclusion, this
study demonstrated the beneficial effect of orlistat on the absorption
of food glycotoxins. (c) 2006 Elsevier Inc. All rights reserved.
ER -