TY - JOUR
TI - Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults
AU - Jaakonmäki, N.
AU - Zedde, M.
AU - Sarkanen, T.
AU - Martinez-Majander, N.
AU - Tuohinen, S.
AU - Sinisalo, J.
AU - Ryödi, E.
AU - Autere, J.
AU - Hedman, M.
AU - Junttola, U.
AU - Huhtakangas, J.K.
AU - Grimaldi, T.
AU - Pascarella, R.
AU - Nordanstig, A.
AU - Bech-Hanssen, O.
AU - Holbe, C.
AU - Busch, R.
AU - Fromm, A.
AU - Ylikotila, P.
AU - Turgut, E.E.
AU - Amorim, I.
AU - Ryliskiene, K.
AU - Tulkki, L.
AU - Pascasio, L.A.
AU - Licenik, R.
AU - Ferdinand, P.
AU - Tsivgoulis, G.
AU - Jatužis, D.
AU - Kõrv, L.
AU - Kõrv, J.
AU - Pezzini, A.
AU - Fonseca, A.C.
AU - Yesilot, N.
AU - Roine, R.O.
AU - Waje-Andreassen, U.
AU - von Sarnowski, B.
AU - Redfors, P.
AU - Huhtakangas, J.
AU - Numminen, H.
AU - Jäkälä, P.
AU - Putaala, J.
AU - the SECRETO Study Group
JO - Journal of Stroke and Cerebrovascular Diseases
PY - 2022
VL - 31
TODO - 5
SP - null
PB - W.B. Saunders
SN - 1052-3057
TODO - 10.1016/j.jstrokecerebrovasdis.2022.106380
TODO - abdominal obesity;  adult;  Article;  body build;  body height;  body mass;  body weight;  cardiovascular risk;  case control study;  confounding variable;  controlled study;  cryptogenic ischemic stroke;  demographics;  educational status;  female;  hip circumference;  human;  major clinical study;  male;  migraine with aura;  obesity;  odds ratio;  prospective study;  risk factor;  sex;  waist circumference;  waist hip ratio
TODO - Objectives: We examined the association between obesity and early-onset cryptogenic ischemic stroke (CIS) and whether fat distribution or sex altered this association. Materials and Methods: This prospective, multi-center, case-control study included 345 patients, aged 18-49 years, with first-ever, acute CIS. The control group included 345 age- and sex-matched stroke-free individuals. We measured height, weight, waist circumference, and hip circumference. Obesity metrics analyzed included body mass index (BMI), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), and a body shape index (ABSI). Models were adjusted for age, level of education, vascular risk factors, and migraine with aura. Results: After adjusting for demographics, vascular risk factors, and migraine with aura, the highest tertile of WHR was associated with CIS (OR for highest versus lowest WHR tertile 2.81, 95%CI 1.43-5.51; P=0.003). In sex-specific analyses, WHR tertiles were not associated with CIS. However, using WHO WHR cutoff values (>0.85 for women, >0.90 for men), abdominally obese women were at increased risk of CIS (OR 2.09, 95%CI 1.02-4.27; P=0.045). After adjusting for confounders, WC, BMI, WSR, or ABSI were not associated with CIS. Conclusions: Abdominal obesity measured with WHR was an independent risk factor for CIS in young adults after rigorous adjustment for concomitant risk factors. © 2022 The Author(s)
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