TY - JOUR
TI - Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study
AU - Drakopoulou, S.
AU - Kontis, E.
AU - Pantiora, E.
AU - Vezakis, A.
AU - Karandrea, D.
AU - Aravidou, E.
AU - Konti-Paphiti, A.
AU - Argyra, E.
AU - Voros, D.
AU - Polydorou, A.A.
AU - Fragulidis, G.P.
JO - Surgery Research and Practice
PY - 2016
VL - 2016
TODO - null
SP - null
PB - Hindawi Limited
SN - 2356-7759, 2356-6124
TODO - 10.1155/2016/4328089
TODO - lornoxicam;  placebo, anastomosis dehiscence;  animal experiment;  animal model;  animal tissue;  Article;  colonic muscle;  controlled study;  experimental study;  fibroblast;  Fisher exact test;  histopathology;  intestine mucosa;  nonhuman;  randomized controlled trial (topic);  rat;  therapy effect
TODO - Introduction and Aim. With the implementation of multimodal analgesia regimens, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are often administered for optimal pain control and reduction of opioid use. The aim of the study was to examine the effects of lornoxicam, a NSAID, on anastomotic healing employing an animal model. Materials and Methods. A total of 28 Wistar rats were randomly assigned in two groups. All animals underwent ascending colonic transection followed by an end-to-end hand sewn anastomosis. Group 1 received intraperitoneally lornoxicam before and daily after surgery. Group 2 received intraperitoneally an equal volume of placebo. Half of the animals in each group were euthanized on the 3rd pod and the remaining on the 7th pod. Macro- and microscopic indicators of anastomotic healing were compared using a two-tailed Fisher exact test. Results. The lornoxicam group significantly decreased fibroblast in growth and reepithelization of the mucosa at the anastomotic site on the 3rd pod and significantly increased occurrence of deep reaching defects, necrosis, and microabscess on the 7th pod. Conclusion. Lornoxicam administration during the perioperative period adversely affects histologic parameters of intestinal anastomotic healing. These effects of lornoxicam administration were not found to induce significant increase of anastomotic dehiscence in the rat model. © 2016 Stamatoula Drakopoulou et al.
ER -