TY - JOUR
TI - Epidemiological characteristics and outcomes from 187 patients with covid-19 admitted to 6 reference centers in greece: an observational study during the first wave of the covid-19 pandemic
AU - Tzouvelekis, A.
AU - Akinosoglou, K.
AU - Karampitsakos, T.
AU - Panou, V.
AU - Tomos, I.
AU - Tsoukalas, G.
AU - Stratiki, M.
AU - Dimakou, K.
AU - Chrysikos, S.
AU - Papaioannou, O.
AU - Hillas, G.
AU - Bakakos, P.
AU - Stratakos, G.
AU - Anagnostopoulos, A.
AU - Koromilias, A.
AU - Boutou, A.
AU - Kioumis, I.
AU - Chloros, D.
AU - Kontakiotis, T.
AU - Papakosta, D.
AU - Papiris, S.
AU - Manali, E.
AU - Antonogiannaki, E.-M.
AU - Koulouris, N.
AU - Bouros, D.
AU - Loukides, S.
AU - Gogos, C.
JO - Advances in Respiratory Medicine
PY - 2021
VL - 89
TODO - 4
SP - 378-385
PB - Via Medica SP Zoo
SN - null
TODO - 10.5603/ARM.a2021.0087
TODO - adult;  artificial ventilation;  diagnosis;  female;  Greece;  human;  intensive care;  male;  middle aged;  procedures;  severity of illness index;  therapy, Adult;  COVID-19;  Critical Care;  Female;  Greece;  Humans;  Male;  Middle Aged;  Respiration, Artificial;  Severity of Illness Index
TODO - Introduction: Epidemiological data from patients with COVID-19 has been recently published in several countries. Nationwide data of hospitalized patients with COVID-19 in Greece remain scarce. Material and methods: This was an observational, retrospective study from 6 reference centers between February 26 and May 15, 2020. Results: The patients were mostly males (65.7%) and never smokers (57.2%) of median age 60 (95% CI: 57.6–64) years. The majority of the subjects (98%) were treated with the standard-of-care therapeutic regimen at that time, including hydroxychloroquine and azithromycin. Median time of hospitalization was 10 days (95% CI: 10–12). Twenty-five (13.3%) individuals were intubated and 8 died (4.2%). The patients with high neutrophil-to-lymphocyte ratio (NLR) (> 3.58) exhibited more severe disease as indicated by significantly increased World Health Organization (WHO) R&D ordinal scale (4; 95% CI: 4–4 vs 3; 95% CI: 3–4, p = 0.0001) and MaxFiO2% (50; 95% CI: 38.2–50 vs 29.5; 95% CI: 21–31, p < 0.0001). The patients with increased lactate dehydrogenase (LDH) levels (>270 IU/ml) also exhibited more advanced disease compared to the low LDH group (< 270 IU/ml) as indicated by both WHO R&D ordinal scale (4; 95% CI: 4–4 vs 4; 95% CI: 3–4, p = 0.0001) and MaxFiO2% (50; 95% CI: 35–60 vs 28; 95% CI: 21–31, p < 0.0001). Conclusion: We present the first epidemiological report from a low-incidence and mortality COVID-19 country. NLR and LDH may represent reliable disease prognosticators leading to timely treatment decisions. © 2021 PTChP.
ER -