TY - JOUR
TI - Extranodal NK/T Cell Lymphoma, Nasal Type with Palatal Involvement: A Rare Case Report and Literature Review
AU - Andreou, A.
AU - Thermos, G.
AU - Sklavounou-Andrikopoulou, A.
JO - JOURNAL OF HEAD AND NECK PATHOLOGY
PY - 2021
VL - 15
TODO - 2
SP - 621-627
PB - Springer-Verlag
SN - 0770-9471
TODO - 10.1007/s12105-020-01182-8
TODO - aged;  case report;  human;  male;  NK T cell lymphoma;  palatine tonsil;  pathology;  soft palate, Aged;  Humans;  Lymphoma, Extranodal NK-T-Cell;  Male;  Palate, Soft;  Palatine Tonsil
TODO - T-cell lymphomas are infrequently encountered in the head and neck area, with the most common subtype being Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT). ENKTL-NT shows a predilection for midline facial structures presenting with ulcerative destructive lesions, whereas palatal involvement is one of the most prominent signs from the oral cavity. Herein, we describe a case of a 76-year-old Greek man with nasal obstruction and an extensive painful necrotic ulcer with ragged borders on the left distal portion of the soft palate and palatine tonsil of 4-months duration. After an initial non-diagnostic biopsy from the nasopharynx, a second incisional biopsy from the palatal lesions was performed. Histopathology was suggestive of an angiocentric lymphoproliferative neoplasm and immunohistochemical examination and in situ hybridization for EBV RNA led to a final diagnosis of ENKTL-NT. The patient was placed under combined chemotherapy and radiotherapy and no recurrence has been noted. Additionally, a retrospective review of the cases in the English literature with an established diagnosis of ENTKL-NT between 2000 and 2019, based on the latest WHO classification of Head and Neck tumors, is performed. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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