TY - JOUR
TI - Expression of the novel tumour suppressor sterile alpha motif and HD domain-containing protein 1 is an independent adverse prognostic factor in classical Hodgkin lymphoma
AU - Xagoraris, I.
AU - Vassilakopoulos, T.P.
AU - Drakos, E.
AU - Angelopoulou, M.K.
AU - Panitsas, F.
AU - Herold, N.
AU - Medeiros, L.J.
AU - Giakoumis, X.
AU - Pangalis, G.A.
AU - Rassidakis, G.Z.
JO - British Journal of Haematology
PY - 2021
VL - 193
TODO - 3
SP - 488-496
PB - Wiley-Blackwell Publishing Ltd
SN - 0007-1048, 1365-2141
TODO - 10.1111/bjh.17352
TODO - bleomycin;  chlormethine;  dacarbazine;  doxorubicin;  membrane protein;  mitoxantrone;  prednisone;  procarbazine;  sterile alpha motif and HD domain containing protein 1;  unclassified drug;  vinblastine;  vincristine;  antineoplastic agent;  bleomycin;  dacarbazine;  deoxynucleoside triphosphate triphosphohydrolase SAMHD1;  doxorubicin;  SAMHD1 protein, human;  vinblastine, adolescent;  adult;  age;  aged;  Article;  cancer prognosis;  cancer staging;  cancer therapy;  classical Hodgkin lymphoma;  clinical feature;  clinical outcome;  cohort analysis;  controlled study;  disease specific survival;  female;  follow up;  freedom from progression;  gender;  histology;  human;  human cell;  immunohistochemistry;  lymph node biopsy;  major clinical study;  male;  overall survival;  patient care;  priority journal;  protein expression;  protein function;  Reed Sternberg cell;  survival;  treatment duration;  biosynthesis;  clinical trial;  disease free survival;  drug effect;  enzymology;  gene expression regulation;  Hodgkin disease;  lymph node;  middle aged;  mortality;  survival rate;  tumor cell line;  very elderly, Adolescent;  Adult;  Aged;  Aged, 80 and over;  Antineoplastic Combined Chemotherapy Protocols;  Bleomycin;  Cell Line, Tumor;  Dacarbazine;  Disease-Free Survival;  Doxorubicin;  Female;  Follow-Up Studies;  Gene Expression Regulation, Enzymologic;  Gene Expression Regulation, Neoplastic;  Hodgkin Disease;  Humans;  Lymph Nodes;  Male;  Middle Aged;  Neoplasm Staging;  SAM Domain and HD Domain-Containing Protein 1;  Survival Rate;  Vinblastine
TODO - The expression patterns and prognostic significance of sterile alpha motif and HD domain-containing protein 1 (SAMHD1) protein in the neoplastic Hodgkin and Reed Sternberg (HRS) cells of Hodgkin lymphoma (HL) were investigated in a cohort of 154 patients with HL treated with standard regimens. SAMHD1 expression was assessed by immunohistochemistry using diagnostic lymph node biopsies obtained prior to treatment. Using an arbitrary 20% cut-off, SAMHD1 was positive in HRS cells of 48/154 (31·2%) patients. SAMHD1 expression was not associated with clinicopathologic parameters, such as age, gender, stage or histologic subtype. In 125 patients with a median follow-up of 90 months (7–401 months), SAMHD1 expression in HRS cells significantly correlated with inferior freedom from progression (FFP) (P = 0·025), disease-specific survival (DSS) (P = 0·013) and overall survival (OS) (P = 0·01). Importantly, in multivariate models together with disease stage, histology subtype and type of treatment as covariates, SAMHD1 expression retained an independent significant association with unfavourable FFP (P = 0·005) as well as DSS (P = 0·022) and OS (P = 0·018). These findings uncover the significance of a novel, adverse prognostic factor in HL that may have therapeutic implications since SAMHD1 inhibitors are now available for clinical use. © 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.
ER -