TY - JOUR
TI - Stress Hyperglycemia in Children and Adolescents as a Prognostic Indicator for the Development of Type 1 Diabetes Mellitus
AU - Argyropoulos, T.
AU - Korakas, E.
AU - Gikas, A.
AU - Kountouri, A.
AU - Kostaridou-Nikolopoulou, S.
AU - Raptis, A.
AU - Lambadiari, V.
JO - FRONTIERS IN PEDIATRICS
PY - 2021
VL - 9
TODO - null
SP - null
PB - Frontiers Media S.A
SN - null
TODO - 10.3389/fped.2021.670976
TODO - autoantibody;  biological marker, adolescent;  disease association;  environmental factor;  genetics;  high risk patient;  human;  hyperglycemia;  insulin dependent diabetes mellitus;  pathophysiology;  pediatric patient;  physiological stress;  prediction;  primary prevention;  prognosis;  Review;  risk factor;  stress hyperglycemia
TODO - Hyperglycemia is a common manifestation in the course of severe disease and is the result of acute metabolic and hormonal changes associated with various factors such as trauma, stress, surgery, or infection. Numerous studies demonstrate the association of adverse clinical events with stress hyperglycemia. This article briefly describes the pathophysiological mechanisms which lead to hyperglycemia under stressful circumstances particularly in the pediatric and adolescent population. The importance of prevention of hyperglycemia, especially for children, is emphasized and the existing models for the prediction of diabetes are presented. The available studies on the association between stress hyperglycemia and progress to type 1 diabetes mellitus are presented, implying a possible role for stress hyperglycemia as part of a broader prognostic model for the prediction and prevention of overt disease in susceptible patients. © Copyright © 2021 Argyropoulos, Korakas, Gikas, Kountouri, Kostaridou-Nikolopoulou, Raptis and Lambadiari.
ER -