TY - JOUR
TI - Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood-brain barrier be a disease “sanctuary” during venetoclax treatment?
AU - Dimou, M.
AU - Bitsani, A.
AU - Roumelioti, M.
AU - Dimitrakopoulou, A.
AU - Iliakis, T.
AU - Pardalis, V.
AU - Grafakos, I.
AU - Kalyva, S.
AU - Markopoulos, A.
AU - Kyrtsonis, M.-C.
AU - Panayiotidis, P.
JO - Clinical Case Reports
PY - 2021
VL - 9
TODO - 4
SP - 2249-2253
PB - Wiley-Blackwell Publishing Ltd
SN - 2050-0904
TODO - 10.1002/ccr3.4002
TODO - azathioprine;  CD20 antigen;  CD23 antigen;  CD5 antigen;  CD79b antigen;  chlorambucil;  corticosteroid;  cyclophosphamide;  cyclosporine;  cytochrome P450 3A;  dexamethasone;  fludarabine;  ibrutinib;  idelalisib;  lactate dehydrogenase;  methotrexate;  petrafocon A HEM larafilcon A;  rituximab;  venetoclax, adult;  Article;  blood brain barrier;  bone marrow biopsy;  carcinomatous meningitis;  case report;  cell infiltration;  cerebrospinal fluid analysis;  chromosomal instability;  chromosome aberration;  chronic lymphatic leukemia;  clinical article;  cytogenetics;  female;  gene mutation;  human;  immunophenotyping;  middle aged;  nuclear magnetic resonance imaging;  Sanger sequencing;  splenomegaly
TODO - Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood-brain barrier and at what extend, especially in reduced doses given for drug-drug interactions. © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
ER -