TY - JOUR
TI - Asthma-like features and anti-asthmatic drug prescription in children with non-cf bronchiectasis
AU - Douros, K.
AU - Sardeli, O.
AU - Prountzos, S.
AU - Galani, A.
AU - Moriki, D.
AU - Alexopoulou, E.
AU - Priftis, K.N.
JO - Journal of Clinical Medicine Research
PY - 2020
VL - 9
TODO - 12
SP - 1-6
PB - MDPI
SN - 1918-3003, 1918-3011
TODO - 10.3390/jcm9124009
TODO - corticosteroid;  immunoglobulin A;  immunoglobulin E;  immunoglobulin G;  immunoglobulin M;  infliximab;  salbutamol, adolescent;  Article;  asthma;  blood cell count;  breathing exercise;  bronchiectasis;  child;  ciliary dyskinesia;  clinical feature;  clinician;  computer assisted tomography;  controlled study;  corticosteroid therapy;  coughing;  Crohn disease;  cystic fibrosis;  disease exacerbation;  disease severity;  dyspnea;  eosinophil count;  female;  forced expiratory volume;  gene mutation;  human;  hyper IgE syndrome;  hypohidrotic ectodermal dysplasia;  immunoglobulin A deficiency;  immunoglobulin blood level;  infant;  lung disease;  major clinical study;  male;  pediatric radiologist;  pediatric ward;  phenotype;  prescription;  prick test;  radiology department;  retrospective study;  spirometry;  tertiary care center;  video microscopy;  wheezing;  x-ray computed tomography
TODO - Bronchiectasis and asthma may share some characteristics and some patients may have both conditions. The present study aimed to examine the rationale of prophylactic inhaled corticosteroids (ICS) prescription in children with bronchiectasis. Data of children with radiologically established bronchiectasis were retrospectively reviewed. Episodes of dyspnea and wheezing, spirometric indices, total serum IgE, blood eosinophil counts, sensitization to aeroallergens, and air-trapping on expiratory CT scans, were recorded. The study included 65 children 1.5–16 years old, with non-CF bronchiectasis. Episodes of dyspnea or wheezing were reported by 22 (33.8%) and 23 (35.4%), respectively. Skin prick tests to aeroallergens (SPTs) were positive in 15 (23.0%) patients. Mosaic pattern on CT scans was observed in 37 (56.9%) patients. Dyspnea, presence of mosaic pattern, positive reversibility test, and positive SPTs were significantly correlated with the prescription of ICS. The prescription of ICS in children with bronchiectasis is more likely when there are certain asthma-like characteristics. The difficulty to set the diagnosis of real asthma in cases of bronchiectasis may justify the decision of clinicians to start an empirical trial with ICS in certain cases. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
ER -