TY - JOUR
TI - Nonalcoholic fatty liver disease in lean subjects: Prognosis, outcomes and management
AU - Chrysavgis, L.
AU - Ztriva, E.
AU - Protopapas, A.
AU - Tziomalos, K.
AU - Cholongitas, E.
JO - World Journal of Gastroenterology
PY - 2020
VL - 26
TODO - 42
SP - 6514-6528
PB - Baishideng Publishing Group Co
SN - 1007-9327
TODO - 10.3748/wjg.v26.i42.6514
TODO - alpha tocopherol;  ezetimibe;  pioglitazone, clinical outcome;  diet therapy;  disease severity;  human;  lean body weight;  lifestyle modification;  metabolism;  nonalcoholic fatty liver;  obesity;  patient care;  physical activity;  prognosis;  Review;  body mass;  complication;  nonalcoholic fatty liver;  obesity, Body Mass Index;  Humans;  Non-alcoholic Fatty Liver Disease;  Obesity;  Overweight;  Prognosis
TODO - Nonalcoholic fatty liver disease (NAFLD) accounts for most cases of chronic liver disease worldwide, with an estimated global prevalence of approximately 25% and ranges from simple steatosis to nonalcoholic steatohepatitis and cirrhosis. NAFLD is strongly connected to metabolic syndrome, and for many years, fatty liver was considered to be an exclusive feature of obese patients. However, recent studies have highlighted the presence of NAFLD in non-obese subjects, with or without increased visceral fat or even in lean subjects without increased waist circumference. “Lean NAFLD” is a relatively new concept and there is significant scientific interest in understanding the differences in pathophysiology, prognosis and management compared with NAFLD in overweight/obese patients. In the present editorial, we discuss the clinical and metabolic profiles and outcomes of lean NAFLD compared with both obese NAFLD and lean healthy individuals from Asian and Western countries. Moreover, we shed light to the challenging topic of management of NAFLD in lean subjects since there are no specific guidelines for this population. Finally, we discuss open questions and issues to be addressed in the future in order to categorize NAFLD patients into lean and non-lean cohorts. © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
ER -