TY - JOUR
TI - Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project
AU - Bassetti, M.
AU - Giacobbe, D.R.
AU - Vena, A.
AU - Trucchi, C.
AU - Ansaldi, F.
AU - Antonelli, M.
AU - Adamkova, V.
AU - Alicino, C.
AU - Almyroudi, M.-P.
AU - Atchade, E.
AU - Azzini, A.M.
AU - Carannante, N.
AU - Carnelutti, A.
AU - Corcione, S.
AU - Cortegiani, A.
AU - Dimopoulos, G.
AU - Dubler, S.
AU - García-Garmendia, J.L.
AU - Girardis, M.
AU - Cornely, O.A.
AU - Ianniruberto, S.
AU - Kullberg, B.J.
AU - Lagrou, K.
AU - Le Bihan, C.
AU - Luzzati, R.
AU - Malbrain, M.L.N.G.
AU - Merelli, M.
AU - Marques, A.J.
AU - Martin-Loeches, I.
AU - Mesini, A.
AU - Paiva, J.-A.
AU - Peghin, M.
AU - Raineri, S.M.
AU - Rautemaa-Richardson, R.
AU - Schouten, J.
AU - Brugnaro, P.
AU - Spapen, H.
AU - Tasioudis, P.
AU - Timsit, J.-F.
AU - Tisa, V.
AU - Tumbarello, M.
AU - Van Den Berg, C.H.S.B.
AU - Veber, B.
AU - Venditti, M.
AU - Voiriot, G.
AU - Wauters, J.
AU - Montravers, P.
JO - Critical Care and Resuscitation
PY - 2019
VL - 23
TODO - 1
SP - null
PB - BioMed Central Ltd.
SN - null
TODO - 10.1186/s13054-019-2497-3
TODO - abdominal infection;  adult;  aged;  Article;  disease severity;  Europe;  female;  hospital admission;  human;  incidence;  intensive care;  intensive care unit;  invasive candidiasis;  liver failure;  major clinical study;  male;  mortality rate;  outcome assessment;  priority journal;  retrospective study;  septic shock;  Sequential Organ Failure Assessment Score;  clinical trial;  complication;  cross infection;  incidence;  invasive candidiasis;  middle aged;  multicenter study;  organization and management;  procedures;  risk factor, Aged;  Candidiasis, Invasive;  Cross Infection;  Europe;  Female;  Humans;  Incidence;  Intensive Care Units;  Male;  Middle Aged;  Outcome Assessment, Health Care;  Retrospective Studies;  Risk Factors
TODO - Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions. © 2019 The Author(s).
ER -