TY - JOUR
TI - Male and female sex hormones in primary headaches
AU - Delaruelle, Z.
AU - Ivanova, T.A.
AU - Khan, S.
AU - Negro, A.
AU - Ornello, R.
AU - Raffaelli, B.
AU - Terrin, A.
AU - Mitsikostas, D.D.
AU - Reuter, U.
JO - The Journal of Headache and Pain
PY - 2018
VL - 19
TODO - 1
SP - null
PB - BioMed Central Ltd.
SN - 1129-2369, 1129-2377
TODO - 10.1186/s10194-018-0922-7
TODO - androgen;  estradiol;  estrogen;  follitropin;  luteinizing hormone;  medroxyprogesterone acetate;  oral contraceptive agent;  prasterone;  progesterone;  prolactin;  sex hormone;  testosterone;  sex hormone, aged;  cluster headache;  female;  hormone substitution;  human;  male;  Medline;  menopause;  menstrual migraine;  meta analysis (topic);  migraine;  migraine with aura;  nonhuman;  primary headache;  priority journal;  Review;  systematic review;  tension headache;  blood;  cluster headache;  migraine;  physiology;  primary headache;  sexual behavior;  sexual characteristics;  tension headache, Cluster Headache;  Female;  Gonadal Steroid Hormones;  Headache Disorders, Primary;  Humans;  Male;  Migraine Disorders;  Sex Characteristics;  Sexual Behavior;  Tension-Type Headache
TODO - Background: The three primary headaches, tension-type headache, migraine and cluster headache, occur in both genders, but all seem to have a sex-specific prevalence. These gender differences suggest that both male and female sex hormones could have an influence on the course of primary headaches. This review aims to summarise the most relevant and recent literature on this topic. Methods: Two independent reviewers searched PUBMED in a systematic manner. Search strings were composed using the terms LH, FSH, progesteron, estrogen, DHEA, prolactin, testosterone, androgen, headach, migrain, "tension type" or cluster. A timeframe was set limiting the search to articles published in the last 20 years, after January 1st 1997. Results: Migraine tends to follow a classic temporal pattern throughout a woman's life corresponding to the fluctuation of estrogen in the different reproductive stages. The estrogen withdrawal hypothesis forms the basis for most of the assumptions made on this behalf. The role of other hormones as well as the importance of sex hormones in other primary headaches is far less studied. Conclusion: The available literature mainly covers the role of sex hormones in migraine in women. Detailed studies especially in the elderly of both sexes and in cluster headache and tension-type headache are warranted to fully elucidate the role of these hormones in all primary headaches. © 2018 The Author(s).
ER -