TY - JOUR
TI - Membranoproliferative glomerulonephritis in a patient with chronic brucellosis
AU - Provatopoulou, S.
AU - Papasotiriou, M.
AU - Papachristou, E.
AU - Gakiopoulou, H.
AU - Marangos, M.
AU - Goumenos, D.S.
JO - Kidney Research and Clinical Practice
PY - 2018
VL - 37
TODO - 3
SP - 298-303
PB - The Korean Society of Nephrology
SN - 2211-9132
TODO - 10.23876/j.krcp.2018.37.3.298
TODO - angiotensin receptor antagonist;  antibiotic agent;  antihypertensive agent;  complement component C3;  complement component C4;  cotrimoxazole;  cryoglobulin;  doxycycline;  hydroxymethylglutaryl coenzyme A reductase inhibitor;  immunoglobulin kappa chain;  immunoglobulin lambda chain;  immunoglobulin M;  prednisolone;  rifampicin, adult;  agglutination test;  agricultural worker;  antibiotic therapy;  antibody titer;  Article;  bacteremia;  bacterial pneumonia;  blood pressure;  Brucella melitensis;  brucellosis;  case report;  clinical article;  clinical examination;  complement blood level;  conservative treatment;  disease exacerbation;  disease severity;  drug dose reduction;  electron microscopy;  estimated glomerular filtration rate;  focal glomerulosclerosis;  follow up;  foot edema;  hematuria;  hepatomegaly;  histopathology;  hospital admission;  human;  human tissue;  hypertension;  interstitial nephritis;  kidney biopsy;  kidney failure;  kidney fibrosis;  male;  medical history;  membranoproliferative glomerulonephritis;  nephrotic syndrome;  patient referral;  percutaneous biopsy;  periorbital edema;  priority journal;  proteinuria;  recurrent infection;  remission;  treatment duration
TODO - Brucellosis is the most common zoonotic disease in Greece, with an endemic distribution and can affect any organ. Infiltration of the renal parenchyma causes acute and chronic interstitial nephritis with granulomas, whereas renal glomeruli are rarely affected. The disease has been sporadically reported, and it causes various histopathologic patterns. Herein, we describe the case of a 39-year-old stock breeder with a history of recurrent episodes of bacteremia caused by Brucella melitensis over a period of 3 years. Two months after the last episode of bacteremia, he presented with mild renal insufficiency, nephrotic range proteinuria, and microscopic hematuria. A renal biopsy revealed membranoproliferative glomerulonephritis with a pattern of focal-segmental nodular sclerosis and moderate tubulointerstitial fibrosis. The patient received antimicrobial and corticosteroid therapy with partial remission of the nephrotic syndrome. © 2018 by The Korean Society of Nephrology.
ER -