TY - JOUR
TI - Beneficial effect of synbiotics on experimental colon cancer in rats
AU - Gavresea, F.
AU - Vagianos, C.
AU - Korontzi, M.
AU - Sotiropoulou, G.
AU - Dadioti, P.
AU - Triantafillidis, J.K.
AU - Papalois, A.E.
JO - Turkish Journal of Gastroenterology
PY - 2018
VL - 29
TODO - 4
SP - 494-501
PB - AVES İbrahim KARA
SN - null
TODO - 10.5152/tjg.2018.17469
TODO - 1,2 dimethylhydrazine;  carcinogen;  synbiotic agent;  antineoplastic agent;  synbiotic agent, aberrant crypt focus;  adult;  animal experiment;  animal model;  animal tissue;  Article;  Bifidobacterium;  Bifidobacterium longum;  cancer survival;  colitis;  colon cancer;  controlled study;  drug effect;  gastrointestinal dysplasia;  inflammation;  Lactobacillus acidophilus;  Lactobacillus casei;  Lactobacillus delbrueckii subsp. bulgaricus;  male;  nonhuman;  rat;  Streptococcus thermophilus;  animal;  chemically induced;  colon;  colon tumor;  microbiology;  precancer, 1,2-Dimethylhydrazine;  Animals;  Anticarcinogenic Agents;  Carcinogens;  Colon;  Colonic Neoplasms;  Male;  Precancerous Conditions;  Rats;  Synbiotics
TODO - Background/Aims: The aim of this study was to investigate the influence of a synbiotic preparation (a mixture of six probiotics and a prebiotic) on aberrant crypt foci (ACF) formation, dysplasia, inflammation, and colitis-like lesions in experimental colon cancer in rats. Materials and Methods: Sixty male rats were categorized into three groups of 20 animals each. Group A was administered 1,2-dimethylydrazine, 15 mg/kg body weight (BW), once a week for 2 weeks. Group B was administered 1,2-dimethylydrazine at the same dose plus synbiotic, started after the second dose of carcinogen and lasted for 5 weeks. Group C was administered synbiotic plus carcinogen from the beginning of the experiment and lasted for 7 weeks. Animals were killed at the end of week 7. Results: At the end of the experiment, the animals that received carcinogen plus the synbiotic had 100%, whereas the animals that received only carcinogen has 70% survival. Animals of groups B and C had significantly lower percentage of inflammation, colitis-like lesions, and ACF dysplasia than animals of group A, whereas those of group C had the least pathological lesions. Conclusion: Synbiotics seem to protect against the appearance of preneoplastic colon lesions in rats. The results of this experimental study suggest that treatment with a synbiotic preparation exerts significant antimutagenic properties against the development of preneoplastic lesions in rats. © Copyright 2018.
ER -