TY - JOUR
TI - Serum magnesium levels and outcomes in patients with acute spontaneous intracerebral hemorrhage
AU - Goyal, N.
AU - Tsivgoulis, G.
AU - Malhotra, K.
AU - Houck, A.L.
AU - Khorchid, Y.M.
AU - Pandhi, A.
AU - Inoa, V.
AU - Alsherbini, K.
AU - Alexandrov, A.V.
AU - Arthur, A.S.
AU - Elijovich, L.
AU - Chang, J.J.
JO - Journal of the American Heart Association
PY - 2018
VL - 7
TODO - 8
SP - null
PB - American Heart Association Inc.
SN - 2047-9980
TODO - 10.1161/JAHA.118.008698
TODO - biological marker;  magnesium, acute disease;  blood;  brain hemorrhage;  female;  follow up;  hematoma;  hemostasis;  hospital admission;  hospital discharge;  hospital mortality;  human;  male;  middle aged;  mortality;  physiology;  prognosis;  retrospective study;  survival rate;  United States, Acute Disease;  Biomarkers;  Cerebral Hemorrhage;  Female;  Follow-Up Studies;  Hematoma;  Hemostasis;  Hospital Mortality;  Humans;  Magnesium;  Male;  Middle Aged;  Patient Admission;  Patient Discharge;  Prognosis;  Retrospective Studies;  Survival Rate;  United States
TODO - Background-—Magnesium (Mg) has potential hemostatic properties. We sought to investigate the potential association of serum Mg levels (at baseline and at 48 hours) with outcomes in patients with acute spontaneous intracerebral hemorrhage (ICH). Methods and Results-—We reviewed data on all patients with spontaneous ICH with available Mg levels at baseline, over a 5-year period. Clinical and radiological outcome measures included initial hematoma volume, admission National Institutes of Health Stroke Scale and ICH scores, in-hospital mortality, favorable functional outcome (modified Rankin Scale scores, 0–1), and functional independence (modified Rankin Scale scores, 0–2) at discharge. Our study population consisted of 299 patients with ICH (mean age, 61±13 years; mean admission serum Mg, 1.8±0.3 mg/dL). Increasing admission Mg levels strongly correlated with lower admission National Institutes of Health Stroke Scale score (Spearman’s r, 0.141; P=0.015), lower ICH score (Spearman’s r, 0.153; P=0.009), and lower initial hematoma volume (Spearman’s r, 0.153; P=0.012). Higher admission Mg levels were documented in patients with favorable functional outcome (1.9±0.3 versus 1.8±0.3 mg/dL; P=0.025) and functional independence (1.9±0.3 versus 1.8±0.3 mg/dL; P=0.022) at discharge. No association between serum Mg levels at 48 hours and any of the outcome variables was detected. In multiple linear regression analyses, a 0.1-mg/dL increase in admission serum Mg was independently and negatively associated with the cubed root of hematoma volume at admission (regression coefficient, 0.020; 95% confidence interval, 0.040 to 0.000; P=0.049) and admission ICH score (regression coefficient, 0.053; 95% confidence interval, 0.102 to 0.005; P=0.032). Conclusions-—Higher admission Mg levels were independently related to lower admission hematoma volume and lower admission ICH score in patients with acute spontaneous ICH. © 2018 The Authors.
ER -