TY - JOUR
TI - Involvement of arterial stiffness and inflammation in hyperuricemia-related development of hypertension
AU - Tomiyama, H.
AU - Shiina, K.
AU - Vlachopoulos, C.
AU - Iwasaki, Y.
AU - Matsumoto, C.
AU - Kimura, K.
AU - Fujii, M.
AU - Chikamori, T.
AU - Yamashina, A.
JO - JOURNAL OF HYPERTENSION
PY - 2018
VL - 72
TODO - 3
SP - 739-745
PB - Lippincott Williams and Wilkins
SN - -
TODO - 10.1161/HYPERTENSIONAHA.118.11390
TODO - C reactive protein;  uric acid;  C reactive protein;  uric acid, adult;  arterial stiffness;  Article;  blood pressure;  cohort analysis;  estimated glomerular filtration rate;  human;  hypertension;  hyperuricemia;  inflammation;  Japanese (people);  major clinical study;  male;  middle aged;  priority journal;  protein blood level;  pulse wave;  uric acid blood level;  ankle brachial index;  arterial stiffness;  blood;  glomerulus filtration rate;  hypertension;  hyperuricemia;  inflammation;  odds ratio;  pathophysiology;  physiology;  risk factor, Adult;  Ankle Brachial Index;  Blood Pressure;  C-Reactive Protein;  Glomerular Filtration Rate;  Humans;  Hypertension;  Hyperuricemia;  Inflammation;  Male;  Middle Aged;  Odds Ratio;  Pulse Wave Analysis;  Risk Factors;  Uric Acid;  Vascular Stiffness
TODO - This study analyzed repeated measurement data to clarify the longitudinal associations between hyperuricemia and the risk factors for the development of hypertension (ie, increased arterial stiffness, renal dysfunction, and inflammation), and then examined whether these risk factors show longitudinal associations with the development of hypertension. In 3274 Japanese men without hypertension, the brachial-ankle pulse wave velocity, blood pressure, estimated glomerular filtration rate, and serum uric acid and CRP (C-reactive protein) levels were measured annually over an 8-year period. Of these, 474 subjects developed hypertension by the end of the study period. Mixed model linear regression analysis revealed a significant longitudinal association of hyperuricemia with increase of the brachial-ankle pulse wave velocity (estimate=5.50, P=0.04), decrease of the estimated glomerular filtration rate (estimate=−2.02, P<0.01), and elevation of the CRP (estimate=0.08×10−1, P=0.02). Hyperuricemia at the study baseline was associated with a significant odds ratio for the development of hypertension by the end of the study period. After adjustments for covariates, the brachial-ankle pulse wave velocity (estimate=0.51×10−2, P<0.01) and CRP (estimate=1.91, P=0.03), but not estimated glomerular filtration rate, were found to show independent longitudinal associations with the new onset of hypertension. In Japanese men without hypertension, hyperuricemia may have a longitudinal association with the development of hypertension, and increased arterials stiffness and inflammation may be involved in the risk of development of hypertension associated with hyperuricemia. © 2018 American Heart Association, Inc.
ER -