TY - JOUR
TI - Addressing unmet needs in understanding asthma mechanisms
AU - Edwards, M.R.
AU - Saglani, S.
AU - Schwarze, J.
AU - Skevaki, C.
AU - Smith, J.A.
AU - Ainsworth, B.
AU - Almond, M.
AU - Andreakos, E.
AU - Belvisi, M.G.
AU - Chung, K.F.
AU - Cookson, W.
AU - Cullinan, P.
AU - Hawrylowicz, C.
AU - Lommatzsch, M.
AU - Jackson, D.
AU - Lutter, R.
AU - Marsland, B.
AU - Moffatt, M.
AU - Thomas, M.
AU - Virchow, J.C.
AU - Xanthou, G.
AU - Edwards, J.
AU - Walker, S.
AU - Johnston, S.L.
AU - Adcock, I.
AU - Akdis, C.
AU - Bel, E.
AU - Bousquet, J.
AU - Ten Brinke, A.
AU - Brusselle, G.
AU - Dáhlen, S.-E.
AU - Djukanovic, R.
AU - Gaga, M.
AU - Garcia-Marcos, L.
AU - Hiemstra, P.
AU - Heffler, E.
AU - Holgate, S.
AU - Kupczyk, M.
AU - Lloyd, C.
AU - Lucas, J.
AU - Magnan, A.
AU - Martin, T.
AU - Myles, D.
AU - Page, C.
AU - Palkonen, S.
AU - Papadopoulos, N.
AU - Papi, A.
AU - Powell, P.
AU - Riley, J.
AU - Sayers, I.
AU - Spanevello, A.
AU - Sterk, P.
AU - Xepapadaki, P.
AU - Wheelock, .C.
AU - members of the EARIP WP2 working group12
JO - The European respiratory journal
PY - 2017
VL - 49
TODO - 5
SP - null
PB - European Respiratory Society
SN - null
TODO - 10.1183/13993003.02448-2016
TODO - allergen;  beta 2 adrenergic receptor stimulating agent;  corticosteroid;  fenoterol;  hormone;  leukotriene receptor blocking agent, air pollution;  asthma;  bacterial infection;  behavior;  Churg Strauss syndrome;  diet;  disease course;  disease exacerbation;  genome-wide association study;  human;  immunological tolerance;  immunoreactivity;  lipidomics;  lung function;  metabolomics;  microbiome;  Mycobacterium tuberculosis;  nonhuman;  pathogenesis;  Pneumovirus;  practice guideline;  priority journal;  respiratory tract inflammation;  Review;  social psychology;  Th2 cell;  virus infection;  whole exome sequencing;  asthma;  consensus development;  disease exacerbation;  economics;  Europe;  medical research;  needs assessment;  pathophysiology;  trends, Asthma;  Biomedical Research;  Consensus Development Conferences as Topic;  Disease Progression;  Europe;  Humans;  Needs Assessment
TODO - Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes. Copyright ©ERS 2017.
ER -