TY - JOUR
TI - Investigation and management of IgM and Waldenström-associated peripheral neuropathies: recommendations from the IWWM-8 consensus panel
AU - D'Sa, S.
AU - Kersten, M.J.
AU - Castillo, J.J.
AU - Dimopoulos, M.
AU - Kastritis, E.
AU - Laane, E.
AU - Leblond, V.
AU - Merlini, G.
AU - Treon, S.P.
AU - Vos, J.M.
AU - Lunn, M.P.
JO - British Journal of Haematology
PY - 2017
VL - 176
TODO - 5
SP - 728-742
PB - Wiley-Blackwell Publishing Ltd
SN - 0007-1048, 1365-2141
TODO - 10.1111/bjh.14492
TODO - alkylating agent;  barbituric acid derivative;  bortezomib;  botulinum toxin;  carfilzomib;  clonazepam;  corticosteroid;  cyclophosphamide;  dexamethasone;  gabapentin;  ibrutinib;  immunoglobulin;  immunoglobulin M;  ixazomib;  prednisolone;  propranolol;  purine derivative;  rituximab;  topiramate;  tricyclic antidepressant agent;  immunoglobulin M, amyloidosis;  Article;  ataxia;  cerebrospinal fluid examination;  computer assisted tomography;  echography;  electromyography;  human;  nerve biopsy;  nerve conduction;  nuclear magnetic resonance imaging;  ophthalmoplegia;  peripheral neuropathy;  phenotype;  plasma exchange;  skin biopsy;  small fiber neuropathy;  Waldenstroem macroglobulinemia;  Paraproteinemias;  Peripheral Nervous System Diseases;  practice guideline;  Waldenstrom Macroglobulinemia, Humans;  Immunoglobulin M;  Paraproteinemias;  Peripheral Nervous System Diseases;  Waldenstrom Macroglobulinemia
TODO - Paraproteinaemic neuropathies are a heterogeneous group of disorders most frequently associated with IgM monoclonal gammopathies including Waldenström macroglobulinaemia (WM). Their consequences are significant for affected patients, and their management challenging for their physicians. The variability in clinical presentation and time course hamper classification and management. The indications for invasive investigations such as cerebrospinal fluid analysis, nerve conduction tests and sensory nerve biopsies are unclear, and the optimum way to measure clinical response to treatment unknown. When to intervene and and how to treat, also present challenges to physicians. As part of its latest deliberations at the International Workshops on WM (IWWM) in London, UK (August 2014), the IWWM8 panel have proposed a consensus approach to the diagnosis and management of peripheral neuropathies associated with IgM monoclonal gammopathies, including WM. Importantly, a consensus regarding the use of clinical outcome measures and recommended models of care for this group of patients is discussed, as well as appropriate treatment interventions. © 2017 John Wiley & Sons Ltd
ER -