TY - JOUR
TI - Granisetron versus tropisetron in the prevention of postoperative nausea and vomiting after total thyroidectomy
AU - Papadima, A.
AU - Gourgiotis, S.
AU - Lagoudianakis, E.
AU - Pappas, A.
AU - Seretis, C.
AU - Antonakis, P.T.
AU - Markogiannakis, H.
AU - Makri, I.
AU - Manouras, A.
JO - Saudi Journal of Anaesthesia
PY - 2013
VL - 7
TODO - 1
SP - 68-74
PB - 
SN - null
TODO - 10.4103/1658-354X.109817
TODO - droperidol;  granisetron;  placebo;  sodium chloride;  tropisetron, adult;  aged;  anesthesia induction;  article;  comparative effectiveness;  controlled study;  dizziness;  double blind procedure;  drug efficacy;  drug induced headache;  drug safety;  female;  human;  major clinical study;  male;  muscle cramp;  myalgia;  postoperative nausea and vomiting;  priority journal;  prospective study;  randomized controlled trial;  thyroidectomy;  visual analog scale
TODO - Background: Postoperative nausea and vomiting (PONV) are frequently encountered after thyroidectomy. For PONV prevention, selective serotonin 5-hydroxytryptamine type 3 (5-HT 3 ) receptor antagonists are considered one of the first-line therapy. We report on the efficiency of granisetron and tropisetron, with that of placebo on the prevention of PONV in patients undergoing total thyroidectomy. Methods: One hundred twenty-seven patients were divided into three groups and randomized to receive intravenously, prior to induction of anesthesia, tropisetron 5 mg, or granisetron 3 mg, or normal saline. All patients received additionally 0.625 mg droperidol. All episodes of postoperative PONV during the first 24 h after surgery were evaluated. Results: Nausea visual analogue scale (VAS) score was lower in tropisetron and granisetron groups than the control group at all measurements ( P<0.01) except for the 8-h measurement for tropisetron ( P=0.075). Moreover, granisetron performed better than tropisetron ( P<0.011 at 4 h and P<0.01 at all other points of time) apart from the 2-h measurement. Vomiting occurred in 22.2%, 27.5%, and 37.5% in granisetron, tropisetron, and control groups, respectively ( P=0.43). Conclusions: The combination of the 5-HT 3 antagonists with droperidol given before induction of anesthesia is well tolerated and superior to droperidol alone in preventing nausea but not vomiting after total thyroidectomy.
ER -