TY - JOUR
TI - Herbal substance, acteoside, alleviates intestinal mucositis in mice
AU - Reinke, D.
AU - Kritas, S.
AU - Polychronopoulos, P.
AU - Skaltsounis, A.L.
AU - Aligiannis, N.
AU - Tran, C.D.
JO - Gastroenterology Research and Practice
PY - 2015
VL - 2015
TODO - null
SP - null
PB - Hindawi Publishing Corporation
SN - 1687-6121, 1687-630X
TODO - 10.1155/2015/327872
TODO - acteoside;  metallothionein;  methotrexate;  myeloperoxidase, animal experiment;  animal model;  animal tissue;  Article;  controlled study;  disease severity;  drug efficacy;  duodenum;  enteritis;  enzyme activity;  histopathology;  ileum;  jejunum;  male;  mouse;  mucosa inflammation;  nonhuman;  prophylaxis;  treatment duration
TODO - This study investigated the role of acteoside in the amelioration of mucositis. C57BL/6 mice were gavaged daily with acteoside 600 g for 5 d prior to induction of mucositis and throughout the experimental period. Mucositis was induced by methotrexate (MTX; 12.5 mg/kg; s.c.). Mice were culled on d 5 and d 11 after MTX. The duodenum, jejunum, and ileum were collected for myeloperoxidase (MPO) activity, metallothionein (MT) levels, and histology. Acteoside reduced histological severity scores by 75, 78, and 88% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5. Acteoside reduced crypt depth by 49, 51, and 33% and increased villus height by 19, 38, and 10% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5. Acteoside decreased MT by 50% compared to MTX-control mice on d 5. Acteoside decreased MPO by 60% and 30% in the duodenum and jejunum, respectively, compared to MTX-controls on d 5. Acteoside alleviated MTX-induced small intestinal mucositis possibly by preventing inflammation. © 2015 Daniel Reinke et al.
ER -