TY - JOUR
TI - Human papillomavirus genotyping and E6/E7 mRNA expression in Greek women with intraepithelial neoplasia and squamous cell carcinoma of the vagina and vulva
AU - Tsimplaki, E.
AU - Argyri, E.
AU - Michala, L.
AU - Kouvousi, M.
AU - Apostolaki, A.
AU - Magiakos, G.
AU - Papassideri, I.
AU - Panotopoulou, E.
JO - Journal of Oncological Science
PY - 2012
VL - null
TODO - null
SP - null
PB - 
SN - 2452-3364
TODO - 10.1155/2012/893275
TODO - virus messenger RNA, adult;  article;  clinical article;  female;  genotype;  Greece;  human;  Human papillomavirus type 16;  Human papillomavirus type 18;  Human papillomavirus type 31;  Human papillomavirus type 33;  Human papillomavirus type 45;  human tissue;  nonhuman;  protein expression;  vagina carcinoma;  vaginal intraepithelial neoplasia;  virus identification;  vulva carcinoma;  Wart virus
TODO - A large proportion of vaginal and vulvar squamous cell carcinomas (SCCs) and intraepithelial neoplasias (VAIN and VIN) are associated with HPV infection, mainly type 16. The purpose of this study was to identify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33, and 45) in 56 histology samples of VAIN, VIN, vaginal, and vulvar SCCs. HPV was identified in 56 of VAIN and 50 of vaginal SCCs, 71.4 of VIN and 50 of vulvar SCCs. E6/E7 mRNA expression was found in one-third of VAIN and in all vaginal SCCs, 42.9 of VIN and 83.3 of vulvar SCCs. Our data indicated that HPV 16 was the commonest genotype identified in VAIN and VIN and the only genotype found in SCCs of the vagina and vulva. These findings may suggest, in accordance with other studies, that mRNA assay might be useful in triaging lesions with increased risk of progression to cancer. Copyright © 2012 Elpida Tsimplaki et al.
ER -