TY - JOUR
TI - In vivo acquisition of a plasmid-mediated blaKPC-2 gene among clonal isolates of Serratia marcescens
AU - Tsakris, A.
AU - Voulgari, E.
AU - Poulou, A.
AU - Kimouli, M.
AU - Pournaras, S.
AU - Ranellou, K.
AU - Kosmopoulou, O.
AU - Petropoulou, D.
JO - Journal of Clinical Microbiology
PY - 2010
VL - 48
TODO - 7
SP - 2546-2549
PB - American Society for Microbiology
SN - 0095-1137, 1098-660X
TODO - 10.1128/JCM.00264-10
TODO - amikacin;  amoxicillin;  amoxicillin plus clavulanic acid;  aztreonam;  carbapenem derivative;  carbapenemase;  cefepime;  cefotaxime;  cefoxitin;  ceftazidime;  ciprofloxacin;  colistin;  ertapenem;  gentamicin;  imipenem;  meropenem;  piperacillin plus tazobactam;  sultamicillin;  tigecycline;  tobramycin;  vancomycin;  antiinfective agent;  bacterial protein;  beta lactamase;  beta-lactamase KPC-2;  carbapenem derivative, adult;  aged;  antibiotic sensitivity;  article;  bacteremia;  bacterial gene;  bacterial strain;  bacterium isolate;  case report;  female;  human;  Klebsiella pneumoniae;  Klebsiella pneumoniae infection;  male;  molecular cloning;  molecular typing;  nonhuman;  plasmid;  pneumonia;  priority journal;  Serratia infection;  Serratia marcescens;  antibiotic resistance;  drug effects;  genetics;  Greece;  isolation and purification;  microbial sensitivity test;  microbiology;  middle aged;  Pneumonia, Bacterial;  pulsed field gel electrophoresis;  Serratia Infections, Klebsiella pneumoniae;  Serratia marcescens, Adult;  Aged;  Anti-Bacterial Agents;  Bacterial Proteins;  beta-Lactam Resistance;  beta-Lactamases;  Carbapenems;  Electrophoresis, Gel, Pulsed-Field;  Female;  Greece;  Humans;  Male;  Microbial Sensitivity Tests;  Middle Aged;  Plasmids;  Pneumonia, Bacterial;  Serratia Infections;  Serratia marcescens
TODO - Three patients admitted to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes. In two of these cases, the patients were initially infected by carbapenem-susceptible S. marcescens isolates. Molecular typing and plasmid analysis suggested that all three patients had clonally indistinguishable isolates of S. marcescens that acquired a plasmid-mediated blaKPC-2 gene during the hospitalization. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
ER -