TY - JOUR TI - Sister Mary Joseph's nodule: Three case reports AU - Larentzakis, A. AU - Theodorou, D. AU - Fili, K. AU - Manataki, A. AU - Bizimi, V. AU - Tibishrani, M. AU - Katsaragakis, S. JO - Cases Journal PY - 2008 VL - 1 TODO - 1 SP - null PB - BioMed Central Ltd. SN - 1757-1626 TODO - 10.1186/1757-1626-1-182 TODO - antineoplastic agent, abdominal tenderness; abdominal wall; adenocarcinoma; adipose tissue; adult; advanced cancer; anemia; Article; cancer chemotherapy; cancer fatigue; case report; clinical examination; colon adenocarcinoma; colon biopsy; colonoscopy; computer assisted tomography; constipation; cystectomy; diarrhea; dysuria; echography; female; gallbladder adenocarcinoma; gallbladder adenocarcinoma; gallbladder cancer; hematuria; human; hydronephrosis; hypertension; lower abdominal pain; male; middle aged; pelvis lymph node; percutaneous biopsy; rectus abdominis muscle; Sister Mary Joseph nodule; transitional cell carcinoma; umbilicus; weight reduction TODO - Background: An umbilical metastatic lesion is called 'Sister Mary Joseph's nodule'. It is an uncommon clinical or radiographic finding, and it is rare as the first sign of a malignant disease. Case presentation: We report three cases of Sister Mary Joseph's nodule. In the three cases presented, the primary tumor was an adenocarcinona of the sigmoid colon, a carcinoma of the bladder, and an adenocarcinoma of the gallbladder, respectively. Conclusion: The differential diagnosis of an umbilical lesion should always include metastatic disease apart from benign lesions and primary neoplasms. © 2008 Larentzakis et al; licensee BioMed Central Ltd. ER -