TY - JOUR
TI - Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers
AU - Vineis, P.
AU - Veglia, F.
AU - Garte, S.
AU - Malaveille, C.
AU - Matullo, G.
AU - Dunning, A.
AU - Peluso, M.
AU - Airoldi, L.
AU - Overvad, K.
AU - Raaschou-Nielsen, O.
AU - Clavel-Chapelon, F.
AU - Linseisen, J.P.
AU - Kaaks, R.
AU - Boeing, H.
AU - Trichopoulou, A.
AU - Palli, D.
AU - Crosignani, P.
AU - Tumino, R.
AU - Panico, S.
AU - Bueno-De-Mesquita, H.B.
AU - Peeters, P.H.
AU - Lund, E.
AU - Gonzalez, C.A.
AU - Martinez, C.
AU - Dorronsoro, M.
AU - Barricarte, A.
AU - Navarro, C.
AU - Quiros, J.R.
AU - Berglund, G.
AU - Jarvholm, B.
AU - Day, N.E.
AU - Key, T.J.
AU - Saracci, R.
AU - Riboli, E.
AU - Autrup, H.
JO - Annals of Oncology
PY - 2007
VL - 18
TODO - 7
SP - 1230-1242
PB - Oxford University Press
SN - 0923-7534, 1569-8041
TODO - 10.1093/annonc/mdm109
TODO - 5,10 methylenetetrahydrofolate reductase (FADH2);  cytochrome P450 1A1;  cytochrome P450 1B1;  glutathione transferase M1;  manganese superoxide dismutase;  reduced nicotinamide adenine dinucleotide phosphate dehydrogenase;  tobacco smoke, adult;  aged;  air pollution;  allele;  article;  bladder cancer;  cancer risk;  case control study;  cohort analysis;  confidence interval;  controlled study;  environmental factor;  female;  gene deletion;  gene interaction;  genetic association;  genetic susceptibility;  genetic variability;  heterozygote;  homozygote;  human;  lung cancer;  major clinical study;  male;  metabolism;  myeloid leukemia;  onset age;  oxidative stress;  priority journal;  risk assessment;  single nucleotide polymorphism;  smoking;  smoking habit;  statistical significance
TODO - Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55. © 2007 European Society for Medical Oncology.
ER -