TY - JOUR
TI - The effect of vitamin K supplementation on biochemical markers of bone
formation in children and adolescents with cystic fibrosis
AU - Nicolaidou, Polyxeni
AU - Stavrinadis, Ilias
AU - Loukou, Ioanna and
AU - Papadopoulou, Anna
AU - Georgouli, Helen
AU - Douros, Konstantinos and
AU - Priftis, Kostas N.
AU - Gourgiotis, Dimitrios
AU - Matsinos, Yiannis G.
AU - and Doudounakis, Stavros
JO - European Journal of Pediatrics
PY - 2006
VL - 165
TODO - 8
SP - 540-545
PB - Springer-Verlag
SN - 0340-6199, 1432-1076
TODO - 10.1007/s00431-006-0132-1
TODO - cystic fibrosis; osteopenia; osteoporosis; vitamin D; vitamin K
TODO - Introductions: Impaired vitamin K status in cystic fibrosis (CF) has
been considered as a newly emerged pathogenetic factor for reduced bone
mineral density (BMD). Objectives: Our aim was to evaluate the
effectiveness of vitamin K supplementation in managing bone formation
abnormalities in children and adolescents with CF. materials and
methods: The statuses of vitamins K and D in relation to biochemical
markers of bone metabolism and BMD were examined in 20 CF children
receiving vitamin D supplements but not vitamin K supplements.
Laboratory tests were carried out at the beginning of the study period
and after 1 year of vitamin K supplementation (10 mg single oral
dose/week) and the results were compared; the results were also compared
with those of 25 healthy controls. Results and discussions: Ten of the
CF patients had BMD z-score <= 2.5 (n=5) or between -1 and -2.5 (n=5).
Biochemical tests on patients before vitamin K supplementation revealed
that the levels of osteoblastic activity markers, namely, bone alkaline
phosphatase (BAP), serum osteocalcin (Gla-OC), serum carboxy-terminal
propeptide of type I procollagen (PICP) and serum amino-terminal
propeptide of type I procollagen (PINP), were significantly reduced
compared with those of the controls. These patients had also lower
25-hydroxy-vitamin D (25(OH)D) and vitamin K serum levels, higher
undercaboxylated osteocalcin (Glu-OC) and parathormone (PTH) levels and
a higher calcium to creatinine ratio (Ca/Cr) than the controls. Vitamin
K intake was associated with an increase in Gla-OC, PINP, PICP levels
and a decrease in Glu-OC levels. PTH levels were lower after vitamin K
supplementation without any difference in BMD z-scores. Conclusions: Our
data indicate that vitamin K supplementation may have a beneficial role
in bone health in CF children.
ER -