TY - JOUR
TI - The association between common vitamin D receptor gene variations and
osteoporosis: A participant-level meta-analysis
AU - Uitterlinden, Andre G.
AU - Ralston, Stuart H.
AU - Brandi, Maria Luisa
AU - and Carey, Alisoun H.
AU - Grinberg, Daniel
AU - Langdahl, Bente L. and
AU - Lips, Paul
AU - Lorenc, Roman
AU - Obermayer-Pietsch, Barbara
AU - Reeve,
AU - Jonathan
AU - Reid, David M.
AU - Amidei, Antonietta
AU - Bassiti, Amelia
AU - and Bustamante, Mariona
AU - Husted, Use Bjerre
AU - Diez-Perez, Adolfo
AU - and Dobnig, Harald
AU - Dunning, Alison M.
AU - Enjuanes, Anna and
AU - Fahrleitner-Pammer, Astrid
AU - Fang, Yue
AU - Karczmarewicz, Elzbieta and
AU - Kruk, Marcin
AU - van Leeuwen, Johannes P. T. M.
AU - Mavilia, Carmelo and
AU - van Meurs, Joyce B. J.
AU - Mangion, Jon
AU - McGuigan, Fiona E. A. and
AU - Pols, Huibert A. P.
AU - Renner, Wilfried
AU - Rivadeneira, Fernando and
AU - van Schoor, Natasja M.
AU - Scollen, Serena
AU - Sherlock, Rachael E. and
AU - Ioannidis, John P. A.
AU - APOSS Investigators
AU - EPOS Investigators and
AU - EPOLOS Investigators
AU - FAMOS Investigators
AU - LASA Investigators and
AU - Rotterdam Study Investigators
AU - GENOMOS Study
JO - ANNALS OF INTERNAL MEDICINE
PY - 2006
VL - 145
TODO - 4
SP - 255-264
PB - AMER COLL PHYSICIANS
SN - 0003-4819
TODO - 10.7326/0003-4819-145-4-200608150-00005
TODO - null
TODO - Background: Polymorphisms of the vitamin D receptor (VDR) gene have been
implicated in the genetic regulation of bone mineral density (BMD).
However, the clinical impact of these variants remains unclear.
Objective: To evaluate the relation between VDR polymorphisms, BMD, and
fractures.
Design: Prospective multicenter large-scale association study.
Setting: The Genetic Markers for Osteoporosis consortium, involving 9
European research teams.
Participants: 26242 participants (18405 women).
Measurements: Cdx2 promoter, FokI, BsmI, ApaI, and TaqI polymorphisms;
BMD at the femoral neck and the lumbar spine by dual x-ray
absorptiometry; and fractures.
Results: Comparisons of BMD at the lumbar spine and femoral neck showed
nonsignificant differences less than 0.011 g/cm(2) for any genotype with
or without adjustments. A total of 6067 participants reported a history
of fracture, and 2088 had vertebral fractures. For all VDR alleles, odds
ratios for fractures were very close to 1.00 (range, 0.98 to 1.02) and
collectively the 95% CIs ranged from 0.94 (lowest) to 1.07 (highest).
For vertebral fractures, we observed a 9% (95% CI, 0% to 18%; P =
0.039) risk reduction for the Cdx2 A-allele (13% risk reduction in a
dominant model).
Limitations: The authors analyzed only selected VDR polymorphisms.
Heterogeneity was detected in some analyses and may reflect some
differences in collection of fracture data across cohorts. Not all
fractures were related to osteoporosis.
Conclusions: The FokI, BsmI, ApaI, and TaqI VDR polymorphisms are not
associated with BMD or with fractures, but the Cdx2 polymorphism may be
associated with risk for vertebral fractures.
ER -