TY - JOUR
TI - IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of
individual participants' data from 21 studies
AU - Huth, Cornelia
AU - Heid, Iris M.
AU - Vollmert, Caren
AU - Gieger,
AU - Christian
AU - Grallert, Harald
AU - Wolford, Johanna K.
AU - Langer,
AU - Birgit
AU - Thorand, Barbara
AU - Klopp, Norman
AU - Hamid, Yasmin H. and
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Lyssenko, Valeriya
AU - Groop, Leif
AU - and Meisinger, Christa
AU - Doring, Angela
AU - Lowel, Hannelore
AU - Lieb,
AU - Wolfgang
AU - Hengstenberg, Christian
AU - Rathmann, Wolfgang
AU - Martin,
AU - Stephan
AU - Stephens, Jeffrey W.
AU - Ireland, Helen
AU - Mather, Hugh and
AU - Miller, George J.
AU - Stringham, Heather M.
AU - Boehnke, Michael and
AU - Tuomilehto, Jaakko
AU - Boeing, Heiner
AU - Mohlig, Matthias
AU - Spranger,
AU - Joachim
AU - Pfeiffer, Andreas
AU - Wernstedt, Ingrid
AU - Niklason, Anders
AU - and Lopez-Bermejo, Abel
AU - Fernandez-Real, Jose-Manuel
AU - Hanson,
AU - Robert L.
AU - Gallart, Luis
AU - Vendrell, Joan
AU - Tsiavou, Anastasia
AU - and Hatziagelaki, Erifili
AU - Humphries, Steve E.
AU - Wichmann, H.
AU - -Erich
AU - Herder, Christian
AU - Illig, Thomas
JO - Frontiers in Diabetes
PY - 2006
VL - 55
TODO - 10
SP - 2915-2921
PB - AMER DIABETES ASSOC
SN - null
TODO - 10.2337/db06-0600
TODO - null
TODO - Several lines of evidence indicate a causal role of the cytokine
interleukin (IL)-6 in the development of type 2 diabetes in humans. Two
common polymorphisms in the promoter of the IL-6 encoding gene IL6,
-174G > C (rs1800795) and -573G > C (rs1800796), have been investigated
for association with type 2 diabetes in numerous studies but with
results that have been largely equivocal. To clarify the relationship
between the two IL6 variants and type 2 diabetes, we analyzed individual
data on > 20,000 participants from 21 published and unpublished studies.
Collected data represent eight different countries, making this the
largest association analysis for type 2 diabetes reported to date. The
GC and CC genotypes of IL6 -174G > C were associated with a decreased
risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a
risk modification of nearly 9%. No evidence for association was found
between IL6 -573G > C and type 2 diabetes. The observed association of
the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides
further evidence for the hypothesis that immune mediators are causally
related to type 2 diabetes; however, because the association is
borderline significant, additional data are still needed to confirm this
finding.
ER -