TY - JOUR
TI - Corticotropin-releasing hormone receptor antagonists
AU - Zoumakis, E.
AU - Grammatopoulos, D. K.
AU - Chrousos, G. P.
JO - European Journal of Endocrinology
PY - 2006
VL - 155
TODO - 1
SP - S85-S91
PB - BioScientifica Ltd
SN - 0804-4643, 1479-683X
TODO - 10.1530/eje.1.02259
TODO - null
TODO - Corticotropin-releasing hormone (CRH), CRH-related peptides, and CRH
receptors play major roles in coordinating the behavioral, endocrine,
autonomic, and immune responses to stress. The wide influence of the CRH
system on physiological processes in both brain and periphery implicates
the respective peptides in the pathophysiology of numerous disorders
characterized by dysregulated stress responses. The potential use of CRH
antagonists is presently under intense investigation. Selective
antagonists have been used experimentally to elucidate the role of
CRH-related peptides in disease processes, such as anxiety and
depression, sleep disorders, addictive behavior, inflammatory disorders,
acute and chronic neurodegeneration, and preterm labor.
ER -