TY - JOUR
TI - Criteria for defining polycystic ovary syndrome as a predominantly
hyperandrogenic syndrome: An Androgen Excess Society guideline
AU - Azziz, Ricardo
AU - Carmina, Enrico
AU - Dewailly, Didier and
AU - Diamanti-Kandarakis, Evanthia
AU - Escobar-Morreale, Hector F. and
AU - Futterweit, Walter
AU - Janssen, Onno E.
AU - Legro, Richard S. and
AU - Norman, Robert J.
AU - Taylor, Ann E.
AU - Witchel, Selma F.
JO - JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
PY - 2006
VL - 91
TODO - 11
SP - 4237-4245
PB - ENDOCRINE SOC
SN - 0021-972X
TODO - 10.1210/jc.2006-0178
TODO - null
TODO - Objective: The Androgen Excess Society (AES) charged a task force to
review all available data and recommend an evidence-based definition for
polycystic ovary syndrome (PCOS), whether already in use or not, to
guide clinical diagnosis and future research.
Participants: Participants included expert investigators in the field.
Evidence: Based on a systematic review of the published peer-reviewed
medical literature, by querying MEDLINE databases, we tried to identify
studies evaluating the epidemiology or phenotypic aspects of PCOS.
Consensus Process: The task force drafted the initial report, following
a consensus process via electronic communication, which was then
reviewed and critiqued by the AES Board of Directors. No section was
finalized until all members were satisfied with the contents and
minority opinions noted. Statements that were not supported by
peer-reviewed evidence were not included.
Conclusions: Based on the available data, it is the view of the AES Task
Force on the Phenotype of PCOS that there should be acceptance of the
original 1990 National Institutes of Health criteria with some
modifications, taking into consideration the concerns expressed in the
proceedings of the 2003 Rotterdam conference. A principal conclusion was
that PCOS should be first considered a disorder of androgen excess or
hyperandrogenism, although a minority considered the possibility that
there may be forms of PCOS without overt evidence of hyperandrogenism
but recognized that more data are required before validating this
supposition. Finally, the task force recognized, and fully expects, that
the definition of this syndrome will evolve over time to incorporate new
research findings.
ER -