TY - JOUR
TI - Preliminary results on the role of PET/CT in initial staging, restaging,
and management of lung cancer
AU - Malamitsi, J.
AU - Valotassiou, B.
AU - Iliadis, K.
AU - Kosmidis, P. and
AU - Laspas, F.
AU - Vasilaki, M.
AU - Pipini, E.
AU - Petounis, A.
AU - Gogou,
AU - L.
AU - Pagou, M.
AU - Dalianis, K.
AU - Efthimiadou, R.
AU - Andreou, J.
JO - NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION
A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
PY - 2006
VL - 569
TODO - 2, SI
SP - 319-322
PB - ELSEVIER SCIENCE BV
SN - null
TODO - 10.1016/j.nima.2006.08.151
TODO - lung cancer; NSCLC; SCLC; SPN; PET/CT; FDG
TODO - Aim: To determine true-positive and true-negative rates of PET/CT
studies in the staging of lung cancer as compared with conventional
imaging (CT and bone scan and occasionally MRI) and the impact of PET/CT
on the treatment strategy in patients with lung cancer. Materials and
method: Twenty patients (21 studies) with known or suspected lung cancer
(14 patients with non-small-cell lung cancer (NSCLC), three patients
with small-cell lung cancer (SCLC), three patients with solitary
pulmonary nodule underwent initial staging (seven studies) or restaging
(14 studies) with combined FDG PET and CT scans on a PET/CT tomograph.
PET/CT images were evaluated separately by two nuclear medicine
physicians and two radiologists specialized on PET, CT, and MRI.
Histology results and a more than 6 months follow-up served as the
reference standards.
Results: Accurate diagnosis was achieved on 16 studies. Site-by-site
analysis gave the following results: 16 true-positive sites (seven on
histology, nine on > 6 months follow-up), six true-negative sites (two
on histology, four on > 6 months follow-up). On PET/CT, six patients
were correctly down-staged, three patients were correctly upstaged and
seven patients were diagnosed correctly as being on the same stage (2/7
with increase of extent of disease, 5/7 with the same extent of
disease). One patient was falsely upstaged and three patients were
falsely down-staged. On the basis of PET/CT results, change of
management was induced in six patients, while in 14 patients there was
no change induced. In five cases PET/CT was partially accurate: on
site-by-site analysis, four sites proved true positive (on histology),
one site false positive (on histology), and four sites false negative
(one on histology, three on > 6 months follow-up).
Conclusion: In our early experience, PET/CT contributed significantly to
correct staging and management of patients with lung cancer. (c) 2006
Elsevier B.V. All rights reserved.
ER -