TY - JOUR
TI - Steroid hormones polymorphisms and cholelithiasis in Greek population
AU - Kitsiou-Tzeli, S.
AU - Giannatou, E.
AU - Spanos, I.
AU - Nicolaidou, P.
AU - and Fretzayas, A.
AU - Tzetis, M.
AU - Lazaris, D.
AU - Kanavakis, E. and
AU - Tsezou, A.
JO - Liver International
PY - 2007
VL - 27
TODO - 1
SP - 61-68
PB - Wiley
SN - 1478-3223, 1478-3231
TODO - 10.1111/j.1478-3231.2006.01385.x
TODO - cholelithiasis; estrogen; androgen receptors; repeat polymorphisms;
steroid hormones
TODO - Background: Genetic variation in genes involved in steroid biosynthesis,
metabolism and signal transduction have been suggested to play a role in
gallstone disease. Methods: To elucidate the possible role of genetic
variation in the estrogen receptors alpha and beta (ER-alpha, ER-beta)
and androgen receptor (AR) genes in breast cancer risk, the
-1174(TA)(n), c.1092+3607(CA)(n) and c.172(CAG)(n) repeat polymorphisms
of the three genes were studied. A case-control cohort of 99 patients
with cholelithiasis and 179 controls were used. Results: No significant
difference was observed in the frequency distribution of -1174(TA)(0-26)
in the ER-alpha gene between patients and controls, while a significant
difference was observed in the frequency distribution of repeat
polymorphism c.1092+3607(CA)(5-27) and c.172(CAG)(5-32) in the ER-beta
gene and AR gene, respectively (P <= 0.0001 and P=0.05, respectively). A
significant difference was observed in the repeat genotype distribution
(SS, SL, LL) in the (CA)(n) of the ER-beta gene (P < 0.0001) and in the
(CAG)(n) of the AR gene (P <= 0.0001). A significantly decreased odds
ratio for cholelithiasis risk was observed in individuals having the SL
and LL genotype for ER-beta gene compared with SS genotype (OR=0.212;
95% CI 0.105-0.426; P < 0.0001 and OR=0.042; 95% CI 0.018-0.097,
respectively) and LL genotype for AR gene (OR=0.622; 95% CI
0.345-1.121; P=0.114 and OR=0.287; 95% CI 0.151-0.543, P < 0.0001,
respectively). This protective effect of SL and LL genotypes for ER-beta
and LL for AR gene remained evident (P < 0.0001 for all of them) even
after adjustment for various risk factors. Conclusions: In conclusion an
association for cholelithiasis risk between short alleles for both
c.1092+3607(CA)(5-27) and c.172(CAG)(5-32) repeat polymorphisms of the
ER-beta and AR was found in individuals of Greek descent.
ER -