TY - JOUR
TI - High-dose ascorbic acid decreases cholesterolernic factors of an
atherogenic diet in guinea pigs
AU - Filis, Konstantinos
AU - Anastassopoulou, Aikaterini
AU - Sigala, Fragiska
AU - and Theodorou, Dimitrios
AU - Manouras, Andreas
AU - Leandros, Emanouel
AU - and Sigalas, Panagiotis
AU - Hepp, Wolfgang
AU - Bramis, John
JO - International journal for vitamin and nutrition research
PY - 2007
VL - 77
TODO - 2
SP - 125-129
PB - Verlag Hans Huber
SN - 0300-9831
TODO - 10.1024/0300-9831.77.2.125
TODO - hyperlipidemia; ascorbic acid; atherosclerosis; cholesterol; diet
TODO - Background: The study evaluates the effect of a high supplemental dose
of ascorbic acid (AA) on plasma concentrations of total cholesterol
(TC), triglycerides (TG), total lipids (TL), and lipoprotein fractions
high-density, very-low-density-, and low-density lipoprotein (HDL, VLDL,
LDL) in guinea pigs fed with atherogenic, diet.
Methods: Group I consisted of 5 normally fed guinea pigs plus a low dose
of AA (1 mg/100 g/day), group II consisted of 7 guinea pigs fed with
food enriched with 2% cholesterol plus a low dose of AA (1 mg/100
g/day), and group III consisted of 7 guinea pigs fed with food enriched
with 2% cholesterol plus a high dose of AA -(30 mg/100 g/day).
Cholesterolemic factors concentrations were determined, after nine
weeks.
Results: Concentrations of TC, TG, TL, LDL, and VLDL were increased in
group II compared to group I (p < 0.01 for all differences).
Supplementation with a high dose of AA resulted in decreased
concentrations of TC (p < 0.01), TG (p < 0.01), TL (p < 0.01), and LDL
(p < 0.01) in group III compared to group II. Additionally,
concentration of HDL was increased in group III compared to group II (p
< 0.01).
Conclusion: High-dose AA supplementation to an atherogenic diet
decreases concentrations of TC, TG, TL, and LDL and increases
concentration of HDL compared to low-dose AA.
ER -