TY - JOUR
TI - Hypertensive patients with false-positive Thallium-201 scintigraphic
results in the infero-posterior wall are in high risk for coronary
artery disease development
AU - Michaelides, Andreas P.
AU - Tousoulis, Dimitrios
AU - Fourlas, Christos
AU - A.
AU - Vyssoulis, Gregory P.
AU - Andrikopoulos, George K. and
AU - Aznaouridis, Konstantinos A.
AU - Stefanadis, Christodoulos I.
JO - International Journal of Cardiology
PY - 2007
VL - 117
TODO - 2
SP - 178-183
PB - Elsevier Ireland Ltd
SN - 0167-5273
TODO - 10.1016/j.ijcard.2006.06.011
TODO - arterial hypertension; Thallium-201 scintigraphy; coronary artery
disease; infero-posterior reversible perfusion defect
TODO - Background: It has been previously postulated that Thallium-201 (Tl-201)
scintigraphy is characterized by relatively low specificity in
hypertensive patients. This study was undertaken to assess any possible
influence of false-positive scintigraphic results on the prognosis of
hypertensive patients.
Methods: The study group comprised 179 consecutive hypertensive patients
(128 men and 51 women), aged 50 7 years, who underwent exercise Tl-201
scintigraphy and coronary angiography (patients with normal
scintigraphic results underwent coronary angiography due to persistent
angina-like symptoms). All patients with normal coronary arteries
underwent a second Tl-201 scintigraphy within 36 +/- 6 months. Patients
with reversible ischemia in the second scintigraphy underwent also a
second coronary angiography.
Results: Coronary artery disease (CAD) was detected in 78 (44%)
patients, while the rest 101 (56%) patients had normal coronary
arteries. Abnormal scintigraphic results were revealed in 66 (85%)
patients with CAD and in 38 (38%) patients without CAD. Twenty-two
(58%) of the 38 hypertensive patients with false-positive scintigraphic
results presented reversible ischemia of the infero-posterior wall of
the left ventricle. Coronary artery disease was detected in 7 (32%) of
these patients during the follow-up period.
Conclusions: Hypertensive patients with normal coronary arteries and
false-positive scintigraphic results usually present with reversible
ischemia of the infero-posterior wall of the left ventricle. This group
of patients seems to be at increased risk of developing CAD in a
long-term follow-up period. (c) 2006 Elsevier Ireland Ltd. All rights
reserved.
ER -