TY - JOUR
TI - Doxazosin for the management of distal-ureteral stones
AU - Liatsikos, E. N.
AU - Katsakiori, P. F.
AU - Assimakopoulos, K. and
AU - Voudoukis, T.
AU - Kallidonis, P.
AU - Constantinides, C. and
AU - Athanasopoulos, A.
AU - Stolzenburg, Jens-Uwe
AU - Perimenis, P.
JO - Journal of Endourology Case Reports
PY - 2007
VL - 21
TODO - 5
SP - 538-541
PB - MARY ANN LIEBERT INC PUBL
SN - null
TODO - 10.1089/end.2006.0107
TODO - null
TODO - Purpose: To evaluate the efficacy of doxazosin in inducing spontaneous
passage of stones in the distal ureter and to compare its efficacy
according to the size of the stone.
Patients and Methods: Seventy-three patients with a mean age of 46.38
+/- 10.17 years who presented with a distal-ureteral stone were divided
into four groups according to stone size and drug treatment: <5 mm
without doxazosin ( group A; n = 15); 5-10 mm ( group B; n = 16); < 5 mm
with doxazosin 4 mg/day for 4 weeks ( group C; n = 20); and 5-10 mm with
doxazosin 4 mg/day for 4 weeks ( group D; n=22). Groups A and B served
as controls for groups C and D, respectively.
Results: Spontaneous stone passage was documented in 9 patients (60%)
in group A v 17 (85%) in group C ( P = 0.047) and 7 ( 43.75%) in group
B v 16 (72.73%) in group D ( P = 0.036). The average expulsion time was
8.78 +/- 1.09 days in group A v 7.59 +/- 0.80 days in group C ( P =
0.004) and 12.14 +/- 1.35 days in group B v 7.06 +/- 1.29 days in group
D ( P < 0.0001). The number of pain episodes in group D patients was
significantly lower than in group B ( P = 0.0078).
Conclusions: Doxazosin treatment proved to be safe and effective for
distal-ureteral stones, as determined by earlier expulsion, decreased
colic frequency, and absence of side effects. The efficacy of doxazosin
was significantly higher for 5- to 10-mm stones than for smaller ones.
ER -