TY - JOUR
TI - Obesity and attenuated adiposity rebound in children with congenital
hypothyroidism. Normalization of BMI values in adolescents
AU - Livadas, S.
AU - Magiakou, M-A.
AU - Mengreli, C.
AU - Girginoudis, P. and
AU - Galani, C.
AU - Smyrnaki, P.
AU - Kanaka-Gantenbein, C.
AU - Xekouki, P.
AU - and Chrousos, G. P.
AU - Dacou-Voutetakis, C.
JO - Hormone and Metabolic Research
PY - 2007
VL - 39
TODO - 7
SP - 524-528
PB - Georg Thieme Verlag KG
SN - 0018-5043, 1439-4286
TODO - 10.1055/s-2007-984396
TODO - adiposity rebound; obesity; thyroid; congenital hypothyroidism; BMI
nadir
TODO - An earlier adiposity rebound, suggestive of adult obesity, has been
reported in children with congenital hypothyroidism. We undertook this
study to evaluate the effect of congenital hypothyroidism on: 1) the
timing of adiposity rebound, 2) the long-term prognosis of BMI status,
and 3) the factors potentially affecting adiposity in subjects with
congenital hypothyroidism. We found that in children with congenital
hypothyroidism the BMI values were higher during the first years of life
compared to normal population, but subsequently normalized. After the
initial rise of BMI, the decline (nadir) and subsequent rise (adiposity
rebound), usually occurring in normal children at an age greater than 30
months, was less evident in our group of children with congenital
hypothyroidism. The severity of hypothyroidism affected BMI values at 6
and 12, but not at 36 months of age. In conclusion, in children with
congenital hypothyroidism, 1) the high BMI values in early childhood
normalize in adolescence, and 2) the normally expected BMI fluctuations
during the first years of life are attenuated. These findings constitute
indirect evidence that thyroid function during fetal and neonatal life
affects BMI status during the first years of life.
ER -