TY - JOUR
TI - Characterization of the lipid profile in dementia and depression in the
elderly
AU - Dimopoulos, Nikolaos
AU - Piperi, Christina
AU - Salonicioti, Aristea and
AU - Psarra, Vassiliki
AU - Mitsonis, Charalampos
AU - Liappas, Loannis and
AU - Lea, Robert W.
AU - Kalofoutis, Anastasios
JO - Journal of Geriatric Psychiatry and Neurology
PY - 2007
VL - 20
TODO - 3
SP - 138-144
PB - SAGE Publications Inc.
SN - 0891-9887, 1552-5708
TODO - 10.1177/0891988707301867
TODO - dementia; depression; elderly; lipids
TODO - The purpose of the study was to examine the association of plasma lipid
concentrations with changes in cognitive function and depressive states
in elderly Greek individuals. The study population consisted of 3
groups: A) 37 subjects with dementia, B) 33 subjects with depression,
and C) 33 controls. All individuals were screened with the Mini-Mental
State Examination (MMSE), the Geriatric Depression Scale (GDS), and an
evaluation of their psychiatric state. Lipid profile was assessed in all
subjects, and the results were statistically evaluated at P <.05 level
of significance. Groups A and B had significantly lower levels of total
plasma cholesterol and HDL cholesterol than group C (P <.01).
Triglyceride levels did not differ significantly between groups A and C,
although they were significantly higher in group B. The results of this
study suggest that an association does exist between the plasma
concentration of cholesterol and HDL-C and depression and/or cognitive
impairment. Further studies are required to explore the significance of
these observations and establish if lipid levels could serve as markers
for diagnostic and therapeutic purposes.
ER -