TY - JOUR
TI - Diagnostic accuracy of two-dimensional shear wave elastography in detecting hepatic fibrosis in children with autoimmune hepatitis, biliary atresia and other chronic liver diseases
AU - Galina, P.
AU - Alexopoulou, E.
AU - Mentessidou, A.
AU - Mirilas, P.
AU - Zellos, A.
AU - Lykopoulou, L.
AU - Patereli, A.
AU - Salpasaranis, K.
AU - Kelekis, N.L.
AU - Zarifi, M.
JO - Pediatric Radiology
PY - 2021
VL - 51
TODO - 8
SP - 1358-1368
PB - Springer Science and Business Media Deutschland GmbH
SN - 0301-0449, 1432-1998
TODO - 10.1007/s00247-020-04959-9
TODO - bilirubin glucuronide, age;  Article;  autoimmune hepatitis;  bile duct atresia;  case control study;  child;  cholestasis;  chronic liver disease;  comparative study;  controlled study;  diagnostic accuracy;  diagnostic test accuracy study;  disease association;  disease severity;  elastography;  female;  human;  human tissue;  intrahepatic cholestasis;  lipoprotein deficiency;  liver fibrosis;  liver stiffness;  male;  meta analysis;  necroinflammation;  nephroblastoma;  portal hypertension;  prospective study;  school child;  sensitivity and specificity;  shear wave elastography;  Shwachman syndrome;  Williams Beuren syndrome;  Wilson disease;  complication;  diagnostic imaging;  elastography;  liver;  liver cirrhosis;  liver disease;  pathology, Biliary Atresia;  Child;  Elasticity Imaging Techniques;  Hepatitis, Autoimmune;  Humans;  Liver;  Liver Cirrhosis;  Liver Diseases
TODO - Background: Although fibrosis is the main determinant of liver stiffness, other disease-related factors usually disregarded in studies on liver elastography, such as inflammation and cholestasis, may influence liver stiffness. Objective: To evaluate the accuracy of two-dimensional (2-D) shear wave elastography in assessing liver fibrosis in children with chronic liver disease by controlling for the confounding role of several disease- and patient-related factors. Materials and methods: Three disease groups were studied: 1) various chronic liver diseases, 2) autoimmune hepatitis and 3) biliary atresia. The METAVIR (meta-analysis of histological data in viral hepatitis) score was used for fibrosis staging and grading of necroinflammatory activity. Multiple linear regression was used to evaluate the relationship between liver stiffness measurements and disease-related factors. The diagnostic accuracy of elastography for predicting fibrosis stages was assessed by calculating the area under the receiver operating characteristic curves. Results: The various chronic liver diseases group (n=32; 7.1±4.9 [mean±standard deviation] years) showed liver stiffness of 8.9±5.0 (mean±standard deviation) kPa, the autoimmune hepatitis group (n=33; 8.1±4.4 years) of 7.1±2.7 kPa, and the biliary atresia group (n=19; 0.2±0.1 years) of 19.7±15.2 kPa. Liver stiffness measurements differed across METAVIR fibrosis categories in all disease groups. The highest values were found in biliary atresia, at fibrosis stages ≥F2 (F2: 12.4±1.6 kPa, F3: 17.8±2 kPa, F4: 41.5±12.4 kPa). Liver stiffness was strongly associated only with fibrosis (P<0.0001) in various chronic liver diseases, but with necroinflammatory activity (P<0.0001) and fibrosis (P=0.002) in autoimmune hepatitis, and with age (P<0.0001), fibrosis (P<0.0001) and cholestasis (P=0.009) in biliary atresia. Optimal cutoffs for detecting advanced fibrosis (≥F3) were 16 kPa (area under curve: 0.98; sensitivity: 87.5%; specificity: 96.7%) in biliary atresia and 8.7 kPa (area under curve: 0.98; sensitivity: 93.8%; specificity: 96.1%) in other chronic liver diseases. Conclusion: Two-dimensional shear wave elastography is reliable in assessing liver fibrosis in children with chronic liver diseases. © 2020, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
ER -